Noninvasive evaluation of diabetic nephropathy using magnetization transfer MRI
| Summary |
Data Summary |
| Investigator |
Takahashi, Takamune |
| Description |
Diabetic nephropathy (DN) is a major diabetic complication that determines the
morbidity and mortality of the diabetic patients. However, currently available
clinical tests or risk factors do not reliably assess its severity or
progression in individual patients, making it difficult to do the targeted and
intensified treatment to high-risk patient populations. One of the major
limitations of current tests is their inability to reliably assess the extent of
renal fibrosis in the affected kidney, even though renal fibrosis is the most
important pathological change to evaluate or predict the long-term outcome of
the patient. Although renal biopsy can diagnose fibrosis, it is invasive and
prone to sampling errors, and does not reliably measure renal fibrosis in the
affected kidney. Thus, a non-invasive test that better evaluate renal fibrosis
in diabetic kidney should greatly improve the assessment of this disease,
enabling better treatment protocol and prognosis.In recent decade, a variety of
magnetic resonance imaging (MRI) methods have been developed andapplied to human
disease including cancer and brain disorders. These techniques have enabled us
toassess the pathological changes in disease organ at molecular and cellular
levels. Magnetization transfer(MT) imaging is a MRI technique that evaluates
large and immobile macromolecules distributed within thetissue and could provide
a means to evaluate the pathological events that are accompanied by the changes
of macromolecular components, such as fibrosis and apoptosis. However, this
method is poorly applied to kidney disease including DN. Therefore, here we will
evaluate the utility of MT imaging in measuring renal fibrosis in diabetic
kidney using a mouse model of progressive DN (db/db eNOS -/- mice). The aims of
thisstudy are: 1) To optimize and establish the MT protocol for mouse kidney
imaging; 2) To examine the correlation between MT data and histological or
biochemical measures of renal fibrosis. Thus, thisapplic
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| Status |
Completed |
| Public Release |
10/1/2016 |
| Data Collected? |
Data will not be collected for this catalog item |
| Species |
M. musculus |
| Animal Age |
Measured In: week(s) post-natal (w) |
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| Data Analysis |
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| Type | Count | Released |
| Animals | 0 | - |
| Experimental Conditions | 0 | - |
| Phenotype Assays | 0 | - |
| Phenotype Measurements | 0 | 0 |
| Microarrays | 0 | - |
| Histology Images | 0 | 0 |
| Publications | 0 | - |
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Experimental Factor Values