Characterization of a new model of diabetic retinopathy
| Summary |
Data Summary |
| Investigator |
Alpers, Charles |
| Description |
Diabetic retinopathy (DR) is a major, common, and specific manifestation of
diabetes, that has been estimated to be present in 86% of T1D patients.
Approximately half of affected patients (42% off all T1D patients), will have
vision-threatening retinopathy. The lack of a good model of this microvascular
complication has hampered development and testing of effective therapeutics for
DR. We present exciting preliminary data that the BTBR ob/ob murine model of
Type II diabetes may develop a proliferative microvascular retinopathy,
concurrently with other retinal and microvascular complications of diabetes. The
development of diabetes and diabetic complications in this model is the
consequence of a genetic mutation resulting in leptin deficiency. Leptin
replacement in these mice has been demonstrated by us to effect the reversal of
diabetes and, in the case of the kidney, reverse the functional and structural
manifestations of advanced diabetic nephropathy. Whether such a dramatic
reversal of DR can also be achieved is unknown. We have been exploring the
possibility of adapting a new imaging technology (OMAG) for studies of diabetic
complications of microvascular origin that can allow investigators to follow the
development of DR lesions sequentially over time in the living mouse. Building
on these advances in diabetic model development, we propose the following
specific aims:
Specific Aim #1: To characterize a new mouse model of diabetic retinopathy (DR)
and to test the potential for reversal of DR by maneuvers previously shown to
reverse diabetic nephropathy in the BTBR ob/ob mouse model of Type 2
Diabetes.Specific Aim #2: to establish a new and non-invasive imaging approach
for monitoring and quantitating the development of DR and its potential reversal
in the live animal setting, that is directly relevant to the management of
humans with DR or at risk to develop DR. Establishing a robust model of DR will
enable us and others to better test therapies of potenti
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| Status |
In Progress |
| Public Release |
10/16/2015 |
| Data Collected? |
Data will not be collected for this catalog item |
| Species |
M. musculus |
| Animal Age |
Measured In: month(s) post-natal (m) |
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| Data Analysis |
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| Type | Count | Released |
| Animals | 0 | - |
| Experimental Conditions | 0 | - |
| Phenotype Assays | 0 | - |
| Phenotype Measurements | 0 | 0 |
| Microarrays | 0 | - |
| Histology Images | 0 | 0 |
| Publications | 0 | - |
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Experimental Factor Values