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Associations of Sedentary Behavior and Screen Time with Human Gut Microbiome
Composition and Diversity.
Authors Antush MT, Balemba OB, Hendricks SA, Flynn M, Geidl R, Vella CA
Submitted By Submitted Externally on 4/25/2024
Status Published
Journal Life (Basel, Switzerland)
Year 2024
Date Published 3/1/2024
Volume : Pages 14 : Not Specified
PubMed Reference
Abstract Human gut microbiome richness, diversity, and composition are associated with
physical activity and impaired glycemic control; however, the associations with
sedentary behavior and screen time are not as well-established. This study
evaluated associations of sedentary behavior and screen time with the alpha
diversity and composition of the human gut microbiome in adults with and without
impaired glycemic control. Sedentary behavior and screen time data were
collected via survey from 47 adults (38% with impaired glycemic control).
Microbiome composition and alpha diversity were determined in fecal microbial
DNA. Sedentary behavior was negatively associated with the number of observed
operational taxonomic units (OTUs), Chao 1 Index, and Fisher's Alpha Index.
These associations were slightly attenuated but remained significant when
controlling for covariates. Screen time was negatively associated with the
number of observed OTUs, Shannon Index, and Fisher's Alpha Index; however, only
the association with observed OTUs was independent of all covariates. Our
findings suggest sedentary behavior and screen time may be significant
influencers of compositional changes in human gut microbiota. This may be a
potential mechanism linking sedentary behavior and screen time to an increased
risk of type 2 diabetes.

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