| Authors |
Maalouf E, Khasawneh H, Karbhari A, AlAsfoor S, Breen-Lyles M, Bernard C, Rajan
E, Farrugia G, Lowe V, Goenka A, Grover M
|
| Submitted By |
Submitted Externally on 4/25/2024 |
| Status |
Published |
| Journal |
Neurogastroenterology and motility |
| Year |
2024 |
| Date Published |
5/1/2024 |
| Volume : Pages |
36 : e14762 |
| PubMed Reference |
|
| Abstract |
Animal models and human data have suggested macrophage-driven immune
dysregulation in diabetic gastroparesis (DG). Translocator protein (TSPO)
upregulation has been suggested to indicate activated state of macrophages and
ER176 is a high affinity third generation TSPO-specific radioligand. The aim of
this study was to determine feasibility of dynamic 11C-ER 176 PET to identify
macrophage activation in DG., Twelve patients, all females, were recruited (4
DG, 4 diabetics, and 4 healthy volunteers) for 11C-ER 176 PET/CT scanning. The
standardized uptake value (SUVmax) in the gastric fundus, body, pylorus, and
descending part of the duodenum were compared between three groups using
Kruskal-Wallis test to perform the comparisons, and a p-value of 0.05 was
considered statistically significant., Age was comparable among the three groups
with a median of 53?years. The uptake was higher in pylorus in diabetics
compared to DG and healthy (SUVmax healthy 4.6?卤?0.2, diabetics 8.4?卤?4.1, DG
5.5?卤?1.0, p?=?0.04). The uptake was similar in gastric fundus (9.0?卤?1.6,
13.1?卤?8.3, 7.8?卤?1.9 respectively, p?=?0.3), body (7.7?卤?1.9, 13?卤?9.2,
7.8?卤?1.9 respectively, p?=?0.8), and duodenum (6.2?卤?2.1, 9.5?卤?6.8, 7.0?卤?1.8
respectively, p?=?0.6). No correlation was observed between SUVmax uptake and
either HbA1C or fasting blood glucose., Female diabetic gastroparesis patients
did not demonstrate increased TSPO ligand 11C-ER 176 uptake in the stomach.
Possible explanations include lack of specificity of ligand for specific
macrophage phenotypes in DG, sex effect, or small sample size. Further studies
investigating non-invasive ways of analyzing immune dysregulation in
neurogastrointestinal disorders are warranted.
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