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Diabetes slows the recovery from urinary incontinence due to simulated childbirth in female rats

Authors Ja-Hong Kim, Xiao Huang, Guiming Liu, Courtenay Moore, James Bena, Margot S. Damaser and Firouz Daneshgari Submitted By Firouz Daneshgari on 2/4/2009 Status Published Journal American journal of physiology. Regulatory, integrative and comparative physiology Year 2007 Date Published 8/1/2007 Volume : Pages 293 : R950 - R955 PubMed Reference Abstract Diabetes slows the recovery from urinary incontinence due to simulated childbirth in female rats. Am J Physiol Regul Integr Comp Physiol 293: R950鈥揜955, 2007. First published May 9, 2007; doi:10.1152/ajpregu.00686.2006.鈥擳his study was done to test the hypothesis that simulated vaginal birth by vaginal distension (VD) causes more severe urinary incontinence and slower recovery in diabetic rats. After measuring baseline leak point pressure (LPP) in 16 diabetes mellitus (DM) and 16 age- and weight-matched control (Ct) female Sprague-Dawley rats, these animals underwent either VD or sham VD (sham). Four and ten days after the procedures, LPP and conscious cystometry were assessed. Tissues were then harvested and examined by light microscopy. LPP at baseline was equal among all four groups. Four days after VD, LPP in both VD groups dropped to significantly lower levels than in sham rats (P 0.001). Moreover, LPP in the DMVD group was significantly lower than in the CtVD group. At 10 days, LPP in the CtVD group had recovered to its baseline value, whereas the LPP in the DMVD group remained significantly reduced. DM rats had larger bladder capacity and longer voiding intervals than Ct rats. Histological findings included more severe damage to the external sphincter striated musculature of the urethra in DMVD group compared with CtVD. In conclusion, these findings suggest that DM causes increased severity and delayed functional recovery from the effects of simulated childbirth.

Investigators with authorship
Name Institution Firouz Daneshgari Case Western Reserve

Complications
All ComplicationsBioinformatics BoneCardiomyopathy CardiovascularGastro-Intestinal (GI) NephropathyNeuropathy & Neurocognition Pediatric Endocrinology Retinopathy UropathyWound Healing