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Publication

A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background.

Authors Davis RC, Schadt EE, Smith DJ, Hsieh EW, Cervino AC, van Nas A, Rosales M, Doss S, Meng H, Allayee H, Lusis AJ Submitted By Richard Davis on 2/11/2009 Status Published Journal Genomics Year 2005 Date Published 9/1/2005 Volume : Pages 86(3) : 259 - 270 PubMed Reference Abstract In the analysis of complex traits, congenic strains are powerful tools because they allow characterization of a single locus in the absence of genetic variation throughout the remainder of the genome. Here, we report the construction and initial characterization of a genome-wide panel of congenic strains derived from the donor strain DBA/2J on the background strain C57BL/6J. For many strains, we have carried out high-density SNP genotyping to precisely map the congenic interval and to identify any contaminating regions. Certain strains exhibit striking variation in litter size and in the ratio of females to males. We illustrate the utility of the set by "Mendelizing" the complex trait of myocardial calcification. These 65 strains cover more than 95% of the autosomal genome and should facilitate the analysis of the many genetic trait differences that have been reported between these parental strains.

Investigators with authorship
Name Institution Richard Davis University of California Los Angeles

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