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The Bioenergetic Health Index: a new concept in mitochondrial translational
research.
Authors Chacko BK, Kramer PA, Ravi S, Benavides GA, Mitchell T, Dranka BP, Ferrick D,
Singal AK, Ballinger SW, Bailey SM, Hardy RW, Zhang J, Zhi D, Darley-Usmar VM
Submitted By Victor Darley-Usmar on 7/2/2014
Status Published
Journal Clinical science (London, England : 1979)
Year 2014
Date Published 9/1/2014
Volume : Pages 127 : 367 - 373
PubMed Reference
Abstract Bioenergetics has become central to our understanding of pathological
mechanisms, the development of new therapeutic strategies and as a biomarker for
disease progression in neurodegeneration, diabetes, cancer and cardiovascular
disease. A key concept is that the mitochondrion can act as the 'canary in the
coal mine' by serving as an early warning of bioenergetic crisis in patient
populations. We propose that new clinical tests to monitor changes in
bioenergetics in patient populations are needed to take advantage of the early
and sensitive ability of bioenergetics to determine severity and progression in
complex and multifactorial diseases. With the recent development of
high-throughput assays to measure cellular energetic function in the small
number of cells that can be isolated from human blood these clinical tests are
now feasible. We have shown that the sequential addition of well-characterized
inhibitors of oxidative phosphorylation allows a bioenergetic profile to be
measured in cells isolated from normal or pathological samples. From these data
we propose that a single value-the Bioenergetic Health Index (BHI)-can be
calculated to represent the patient's composite mitochondrial profile for a
selected cell type. In the present Hypothesis paper, we discuss how BHI could
serve as a dynamic index of bioenergetic health and how it can be measured in
platelets and leucocytes. We propose that, ultimately, BHI has the potential to
be a new biomarker for assessing patient health with both prognostic and
diagnostic value.


Investigators with authorship
NameInstitution
Victor Darley-UsmarUniversity of Alabama at Birmingham

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