看片视频


Mitochondria in monocytes and macrophages-implications for translational and
basic research.
Authors Ravi S, Mitchell T, Kramer PA, Chacko B, Darley-Usmar VM
Submitted By Victor Darley-Usmar on 12/8/2014
Status Published
Journal The international journal of biochemistry & cell biology
Year 2014
Date Published 8/1/2014
Volume : Pages 53 : 202 - 207
PubMed Reference
Abstract The mitochondrion plays a crucial role in the immune system particularly in
regulating the responses of monocytes and macrophages to tissue injury,
pathogens, and inflammation. In systemic diseases such as atherosclerosis and
chronic kidney disease (CKD), it has been established that disruption of
monocyte and macrophage function can lead to chronic inflammation. Polarization
of macrophages into the pro-inflammatory (M1) and anti-inflammatory (M2)
phenotypes results in distinct metabolic reprograming which corresponds to the
progression and resolution of inflammation. In this review, we will discuss the
role of the mitochondrion in monocyte and macrophage function and how these
cells specifically influence the pathophysiology of atherosclerosis and CKD. We
propose that assessing monocyte bioenergetics in different disease states could
(1) enhance our understanding of the energetic perturbations occurring in
systemic inflammatory conditions and (2) aid in identifying therapeutic
interventions to mitigate these disorders in patients.


Investigators with authorship
NameInstitution
Victor Darley-UsmarUniversity of Alabama at Birmingham

Complications