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Publication

Akt1 in the cardiovascular system: friend or foe?

Authors O'Neill BT, Abel ED Submitted By E. Dale Abel on 3/4/2015 Status Published Journal The Journal of clinical investigation Year 2005 Date Published 8/1/2005 Volume : Pages 115 : 2059 - 2064 PubMed Reference Abstract Akt is an important signaling molecule that modulates many cellular processes such as cell growth, survival, and metabolism. Akt activation has been proposed as a potential strategy for increasing cardiomyocyte survival following ischemia. In mammalian cells, 3 distinct isoforms of Akt exist, but their precise roles in cardiovascular biology were previously unknown. Three separate studies published in this issue of the JCI now provide important new insight into the central role of Akt1 in the regulation of angiogenesis and the maladaptive or deleterious consequences of chronic unregulated Akt activation in the heart (see the related articles beginning on pages 2108, 2119, and 2128). Here we discuss the implications of these exciting new studies.

Investigators with authorship
Name Institution E. Dale Abel University of Iowa

Complications
All ComplicationsBioinformatics BoneCardiomyopathy CardiovascularGastro-Intestinal (GI) NephropathyNeuropathy & Neurocognition Pediatric Endocrinology Retinopathy UropathyWound Healing