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Publication

MRI of Rod Cell Compartment-specific Function in Disease and Treatment In Vivo.

Authors Berkowitz BA, Bissig D, Roberts R Submitted By Bruce Berkowitz on 9/8/2015 Status In press Journal Progress in retinal and eye research Year 2015 Date Published 9/3/2015 Volume : Pages Not Specified : Not Specified PubMed Reference Abstract Rod cell oxidative stress is a major pathogenic factor in retinal disease, such as diabetic retinopathy (DR) and retinitis pigmentosa (RP). Personalized, non-destructive, and targeted treatment for these diseases remains elusive since current imaging methods cannot analytically measure treatment efficacy against rod cell compartment-specific oxidative stress in vivo. Over the last decade, novel MRI-based approaches that address this technology gap have been developed. This review summarizes progress in the development of MRI since 2006 that enables earlier evaluation of the impact of disease on rod cell compartment-specific function and the efficacy of anti-oxidant treatment than is currently possible with other methods. Most of the new assays of rod cell compartment-specific function are based on endogenous contrast mechanisms, and this is expected to facilitate their translation into patients with DR and RP, and other oxidative stress-based retinal diseases.

Investigators with authorship
Name Institution Bruce Berkowitz Wayne State University

Complications
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