| Authors |
Kim C, Pop-Busui R, Braffett B, Cleary PA, Bebu I, Wessells H, Orchard T, Sarma
AV,
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| Submitted By |
Aruna Sarma on 11/30/2015 |
| Status |
Published |
| Journal |
The journal of sexual medicine |
| Year |
2015 |
| Date Published |
11/1/2015 |
| Volume : Pages |
Not Specified : Not Specified |
| PubMed Reference |
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| Abstract |
Previous studies have reported that lower testosterone concentrations are
associated with cardiovascular autonomic neuropathy (CAN), a risk factor for
cardiovascular events. However, no studies have examined this relationship in
men with type 1 diabetes, who are at high risk for CAN., The aim of this study
was to examine the associations between testosterone concentrations and measures
of CAN in a large, well-characterized cohort of men with type 1 diabetes., We
conducted an analysis of men in the Diabetes Control and Complications Trial
(DCCT), a randomized trial of intensive glucose control, and its observational
follow-up the Epidemiology of Diabetes Intervention and Complications (EDIC)
Study. Testosterone was measured by liquid chromatography mass spectrometry in
stored samples from EDIC follow-up years 10 and 17. Regression models were used
to assess the cross-sectional relationships between testosterone and CAN
measures., The main CAN measure from EDIC follow-up year 17 was a standardized
composite of R-R variation with paced breathing?combined with either a Valsalva ratio?=?1.5 or a decrease in diastolic blood
pressure?>?10?mm?Hg upon standing. Continuous R-R variation and Valsalva ratio
were secondary outcomes., Lower total and bioavailable testosterone
concentrations at follow-up years 10 and 17 were not associated with the
presence of CAN at year 17. In analyses using Valsalva ratio as a continuous
measure, higher total (P?=?0.01) and bioavailable testosterone concentrations
(P?=?0.005) were associated with a higher (more favorable) Valsalva ratio after
adjustment for covariates including age, body mass index, smoking status,
hypertension, and glycemia., Testosterone levels are not associated with CAN
among men with type 1 diabetes. Although testosterone is associated with a
higher Valsalva ratio, a more favorable indicator, the clinical significance of
this association is not known. Kim C, Pop-Busui R, Braffett B, Cleary PA, Bebu
I, Wessells H, Orchard T, and Sarma AV, for the DCCT/E.D.I.C. Research Group.
Testosterone concentrations and cardiovascular autonomic neuropathy in men with
type 1 diabetes in the Epidemiology of Diabetes Interventions and Complications
Study (EDIC). J Sex Med **;**:**-**.
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