| Authors |
Kim C, Bebu I, Braffett B, Cleary PA, Arends V, Steffes M, Wessells H, Orchard
T, Sarma AV,
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| Submitted By |
Aruna Sarma on 1/6/2016 |
| Status |
Published |
| Journal |
Clinical endocrinology |
| Year |
2015 |
| Date Published |
|
| Volume : Pages |
84 : 693 - 9 |
| PubMed Reference |
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| Abstract |
Low testosterone concentrations have been reported to be associated with
increased risk of congestive heart failure, but the mechanisms are unclear. Our
objective was to examine the relationship between endogenous testosterone and
measures of cardiac mass and function among men with type 1 diabetes., Secondary
analysis of a prospective observational study., Men (n = 508) in the
Epidemiology of Diabetes Interventions and Complications (EDIC) study, the
observational follow-up of the Diabetes Control and Complications Trial (DCCT).,
Testosterone assessed by liquid chromatography mass spectrometry at EDIC year 10
and cardiac magnetic resonance imaging (CMR) measures at EDIC years 14/15.
Linear regression models were used to assess the relationship between
testosterone, sex hormone binding globulin (SHBG) and left ventricular (LV)
mass, volume, ejection fraction and cardiac index before and after adjustment
for age, randomization arm, alcohol and cigarette use, macroalbuminuria,
haemoglobin A1c, insulin dose, body mass index, lipids, blood pressure, use of
antihypertensive medications and microvascular complications., In fully adjusted
models, total testosterone concentrations were significantly associated with LV
mass (P = 0路014), end-diastolic volume (P = 0路002), end-systolic volume (P =
0路012) and stroke volume (P = 0路022), but not measures of LV function after
adjustment for cardiac risk factors. Bioavailable testosterone was associated
with LV mass, but not volume or function, while SHBG was associated with volume,
but not mass or function., Among men with type 1 diabetes, higher total
testosterone was associated with higher LV mass and volume, but not with
function. The clinical significance of this association remains to be
established.
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