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An Universal packaging technique for low-drift implantable pressure sensors.
Authors Kim A, Powell CR, Ziaie B
Submitted By Submitted Externally on 6/17/2016
Status Published
Journal Biomedical microdevices
Year 2016
Date Published
Volume : Pages 18 : 32
PubMed Reference
Abstract Monitoring bodily pressures provide valuable diagnostic and prognostic
information. In particular, long-term measurement through implantable sensors is
highly desirable in situations where percutaneous access can be complicated or
dangerous (e.g., intracranial pressure in hydrocephalic patients). In spite of
decades of progress in the fabrication of miniature solid-state pressure
sensors, sensor drift has so far severely limited their application in
implantable systems. In this paper, we report on a universal packaging technique
for reducing the sensor drift. The described method isolates the pressure sensor
from a major source of drift, i.e., contact with the aqueous surrounding
environment, by encasing the sensor in a silicone-filled medical-grade
polyurethane balloon. In-vitro soak tests for 100聽days using commercial
micromachined piezoresistive pressure sensors demonstrate a stable operation
with the output remaining within 1.8 cmH2O (1.3聽mmHg) of a reference pressure
transducer. Under similar test conditions, a non-isolated sensor fluctuates
between 10 and 20 cmH2O (7.4-14.7聽mmHg) of the reference, without ever settling
to a stable operation regime. Implantation in Ossabow pigs demonstrate the
robustness of the package and its in-vivo efficacy in reducing the baseline
drift.


Investigators with authorship
NameInstitution
Charles PowellIndiana University-Purdue University-Indianapolis

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