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The Haptoglobin genotype predicts cardio-renal mortality in type 1 diabetes.
Authors Costacou T, Orchard TJ
Submitted By Tina Costacou on 10/28/2016
Status Published
Journal Journal of diabetes and its complications
Year 2016
Date Published 3/1/2016
Volume : Pages 30 : 221 - 6
PubMed Reference
Abstract The Haptoglobin (HP) 2-2 genotype increases cardiovascular diabetes complication
incidence. In type 1 diabetes, HP 2-2 also predicts declining kidney function
and end-stage renal disease. We investigated whether HP 2-2 predisposes to
cardio-renal mortality, while considering other causes of death as competing
risks., Individuals with type 1 diabetes and HP data available (n=486; mean
baseline age, 27 and duration, 19 years) were selected for study. Vital status
was assessed as of 8/31/2014. The underlying cause of death was determined and
classified based on standardized procedures., During 25 years of follow-up, 79
(16.3%) cardio-renal deaths and 43 (8.8%) deaths related to other causes
occurred. Although total mortality did not differ by HP (25.4% with HP 1 versus
24.6% with HP 2-2, p=0.84), a greater proportion of HP 2-2 carriers exhibited a
cardio-renal death (19.0 versus 14.2, p=0.05). In time-to-event analyses, HP 2-2
was associated with a statistically significant increase of the sub-distribution
hazard ratio for cardio-renal mortality (HR=1.64, p=0.03), although this effect
was somewhat attenuated after multivariable adjustment (HR=1.58, p=0.05)., Our
results suggest that in addition to predicting the incidence of cardio-renal
complications, HP 2-2 also increases susceptibility for cardio-renal mortality
in type 1 diabetes. These findings require validation in other cohorts.

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