| Authors |
Costacou T, Levy AP, Miller RG, Snell-Bergeon J, Asleh R, Farbstein D, Fickley
CE, Pambianco G, de la Vega R, Evans RW, Orchard TJ
|
| Submitted By |
Tina Costacou on 10/28/2016 |
| Status |
Published |
| Journal |
Acta diabetologica |
| Year |
2016 |
| Date Published |
4/1/2016 |
| Volume : Pages |
53 : 243 - 50 |
| PubMed Reference |
|
| Abstract |
Haptoglobin (Hp) genotype 2-2 increases cardiovascular diabetes complications.
In type 2 diabetes, a-tocopherol was shown to lower cardiovascular risk in Hp
2-2, potentially through HDL function improvements. Similar type 1 diabetes data
are lacking. We conducted a randomized crossover pilot of a-tocopherol
supplementation on HDL function [i.e., cholesterol efflux (CE) and
HDL-associated lipid peroxides (LP)] and lipoprotein subfractions in type 1
diabetes., Hp genotype was assessed in members of two Allegheny County, PA, type
1 diabetes registries and the CACTI cohort; 30 were randomly selected within Hp
genotype, and 28 Hp 1-1, 31 Hp 2-1 and 30 Hp 2-2 were allocated to daily
a-tocopherol or placebo for 8聽weeks with a 4-week washout., Baseline CE
decreased with the number of Hp 2 alleles (p-trend聽=聽0.003). There were no
differences in LP or lipoprotein subfractions. In intention-to-treat analysis
stratified by Hp, a-tocopherol increased CE in Hp 2-2 (脽聽=聽0.79, p聽=聽0.03) and
LP in Hp 1 allele carriers (脽 Hp 1-1聽=聽0.18, p聽=聽0.05; 脽 Hp 2-1聽=聽0.21,
p聽=聽0.07); reduced HDL particle size (脽聽=聽-0.07, p聽=聽0.03) in Hp 1-1 carriers;
increased LDL particle concentration in Hp 1-1; and decreased it in Hp 2-2
carriers. However, no significant interactions were observed by Hp., In this
type 1 diabetes study, HDL function worsened with the number of Hp 2 alleles.
a-Tocopherol improved HDL function in Hp 2-2 carriers and appeared to adversely
affect lipid peroxides and lipoprotein subfractions among Hp 1 allele carriers.
As no significant interactions were observed, findings require replication in
larger studies.
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