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Evidence for a critical role of panretinal pathophysiology in experimental ROP.
Authors Berkowitz BA, Roberts R
Submitted By Bruce Berkowitz on 3/31/2010
Status Published
Journal Documenta ophthalmologica. Advances in ophthalmology
Year 2010
Date Published 2/1/2010
Volume : Pages 120 : 13 - 24
PubMed Reference
Abstract In this review, we summarize our in vivo studies of retinal pathophysiology in
experimental models of retinopathy of prematurity, which were largely focused on
the temporal and spatial links between retinal neovascularization (NV), vascular
oxygenation, and intraretinal ion regulation. These studies were made possible
through the use of magnetic resonance methods. Prior to the phenotype change
from normal vessel development to NV, we found little support for a pathogenic
role of focal retinal hypoxia at the border of vascular and avascular retina.
However, key links were found between retinal NV and functional panretinal
defects in both oxygenation to a provocation and intraretinal ion regulation.
Through a treatment which reduced NV incidence but not panretinal
pathophysiology, proliferative disease was found to last longer than that in the
untreated group. These considerations provide compelling evidence that clinical
attention directed toward reducing retinal NV should include approaches that
reduce functional panretinal pathophysiology.


Investigators with authorship
NameInstitution
Bruce BerkowitzWayne State University

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