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Validation of structural and functional lesions of diabetic retinopathy in mice.
Authors Kern TS, Tang J, Berkowitz BA
Submitted By Bruce Berkowitz on 10/26/2010
Status Published
Journal Molecular vision
Year 2010
Date Published
Volume : Pages 16 : 2121 - 31
PubMed Reference
Abstract Diabetic retinopathy is a serious long-term complication of diabetes mellitus.
There is considerable interest in using mouse models, which can be genetically
modified, to understand how retinopathy develops and can be inhibited. Not all
retinal lesions that develop in diabetic patients have been reproduced in
diabetic mice; conversely, not all abnormalities found in diabetic mice have
been studied or identified in diabetic patients. Thus, it is important to
recognize which structural and functional abnormalities that develop in diabetic
mice have been validated against the lesions that characteristically develop in
diabetic patients. Those lesions that have been observed to develop in the mouse
models to date are predominantly characteristic of the early stages of
retinopathy. Identification of new therapeutic ways to inhibit these early
lesions is expected to help inhibit progression to more advanced and clinically
important stages of retinopathy.


Investigators with authorship
NameInstitution
Bruce BerkowitzWayne State University

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