看片视频


Lipid peroxidation regulates podocyte migration and cytoskeletal structure
through redox sensitive RhoA signaling.
Authors Kruger C, Burke SJ, Collier JJ, Nguyen TT, Salbaum JM, Stadler K
Submitted By Krisztian Stadler on 4/2/2018
Status Published
Journal Redox biology
Year 2018
Date Published 3/1/2018
Volume : Pages 16 : 248 - 254
PubMed Reference
Abstract Early podocyte loss is characteristic of chronic kidney diseases (CKD) in
obesity and diabetes. Since treatments for hyperglycemia and hypertension do not
prevent podocyte loss, there must be additional factors causing podocyte
depletion. The role of oxidative stress has been implicated in CKD but it is not
known how exactly free radicals affect podocyte physiology. To assess this
relationship, we investigated the effects of lipid radicals on podocytes, as
lipid peroxidation is a major form of oxidative stress in diabetes. We found
that lipid radicals govern changes in podocyte homeostasis through redox
sensitive RhoA signaling: lipid radicals inhibit migration and cause loss of
F-actin fibers. These effects were prevented by mutating the redox sensitive
cysteines of RhoA. We therefore suggest that in diseases associated with
increased lipid peroxidation, lipid radicals can determine podocyte function
with potentially pathogenic consequences for kidney physiology.

Complications