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Testosterone Concentrations and Cardiovascular Disease in Men with Type 1 Diabetes
Summary Data Summary
Applicant Sarma, Aruna
E-Mail Address asarma@umich.edu
Project Title Testosterone Concentrations and Cardiovascular Disease in Men with Type 1
Diabetes
CBU ID 14GHSU1353
External SubContract ID 25034-51
Diabetic Complication Uropathy
Funding Program Group Pilot & Feasibility [PF2014]
Abstract In men, low endogenous levels of testosterone (T) are associated with increased
risk of cardiovascular disease (CVD). It is unclear whether this relationship is
independent of age, obesity, and conventional CVD risk factors such as levels of
blood pressure and lipids. The majority of studies are cross-sectional and
cannot examine changes in T or risk factor levels. Prospective studies of T and
CVD risk are needed particularly for men with type 1 diabetes (T1D) for several
reasons. Men with T1D may have as much as a 10-fold increased risk for CVD
mortality compared to men without diabetes. This risk may be compounded by the
lower bioavailable T levels in men with T1D compared to men without diabetes; as
many as 1 in 5 men with T1D may have low bioavailable T. The need to understand
T and its risks is more urgent due to the tripling in prescriptions for
exogenous T over the past decade. We propose to address these important clinical
questions by leveraging the extensive resources of DCCT/EDIC, a large randomized
trial of intensive glycemic control in T1D and its observational follow-up to
complete these aims: 1) to examine how changes in T levels predict changes in
CVD risk factors among men with T1D. We hypothesize that decreases in T levels
will predict increases in blood pressure, triglycerides, hemoglobin A1c, and
decreases in high-density lipoprotein, before and after adjustment for age and
obesity; 2) to examine how T levels predict cardiac structure and function on
cardiac MRI among men with T1D. We hypothesize that lower T levels will predict
lower values of left ventricular mass and end-diastolic volume, before and after
adjustment for age, obesity, hemoglobin A1c, blood pressure, and lipid levels;
and 3) to examine how changes in Tlevels predict CVD events among men with T1D.
We hypothesize that lower T levels will predict a greater incidence of CVD
events, before and after adjustment for age, obesity, hemoglobin A1c, blood
pressure, and lipid levels. By examining a cohort at high-risk for CVD and which
has serial measures of CVD risk factors as well as structure, function, and
adjudicated events, we can examine whether T is related to CVD in the type 1
population, as well as illuminating the relationships between T and risk factors
generally.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 36014
Supply Total Costs 79
Equipment Total Costs 0
Travel/Other Total Costs 30000
Direct Costs 66093
Indirect Costs Proposed 33907
Total Costs Proposed 100000
Total Costs Approved 100000
Start Date 10/1/2014
End Date 9/30/2016
IFO Name Vogler, Colleen
IFO E-Mail Address clv@umich.edu
IACUC/IRB No. HUM00032847
IACUC/IRB Institution University of Michigan-Ann Arbor
Entity ID No.
Report Request Date 10/30/2016
T1D NO
TypeCount
Invoices 24
Progress Reports 2
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor9/7/2016$2,088.43$1,148.63$3,237.06-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor9/4/2015$12,284.54-$12,284.54-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor8/6/2015$4,439.08-$4,439.08-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor8/4/2016$3,687.11$2,027.91$5,715.02-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor7/7/2016$3,201.68$1,760.92$4,962.60-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor7/7/2015$4,571.39-$4,571.39-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor6/6/2016$1,467.19$806.95$2,274.14-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor6/5/2015$4,451.60-$4,451.60-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor5/6/2015$4,451.64-$4,451.64-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor5/5/2016$1,984.97$297.25$2,282.22-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor4/6/2016$1,125.80$619.19$1,744.99-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor4/6/2015$4,451.60-$4,451.60-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor3/5/2015$4,451.60-$4,451.60-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor3/4/2016$1,465.47$806.01$2,271.48-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor2/5/2015$4,700.37-$4,700.37-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor2/4/2016$1,809.65$995.31$2,804.96-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor12/4/2015$4,949.80-$4,949.80-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor12/12/2014$8,293.11-$8,293.11- 
  View  14GHSU135325034-51University of Michigan-Ann Arbor11/5/2015$5,623.73-$5,623.73-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor10/7/2015$4,406.14-$4,406.14-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor10/21/2016---- 
  View  14GHSU135325034-51University of Michigan-Ann Arbor1/7/2016$2,724.73-$2,724.73-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor1/7/2015$4,146.58-$4,146.58-View PDF
  View  14GHSU135325034-51University of Michigan-Ann Arbor1/10/2017$681.59$374.88$1,056.47-View PDF
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