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Diffusion Tensor Imaging MRI: A Novel Biomarker for Early Diabetic Nephropathy
Summary Data Summary
Applicant Dell, Katherine
E-Mail Address katherine.dell@case.edu
Project Title Diffusion Tensor Imaging MRI: A Novel Biomarker for Early Diabetic Nephropathy
CBU ID 14GHSU1377
External SubContract ID 25732-55
Diabetic Complication Nephropathy
Funding Program Group Pilot & Feasibility [PF2014]
Abstract Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD)
in the United States. Its prevalence is increasing worldwide and will likely
increase further as the epidemic of type 2 diabetes mellitus (T2DM) worsens.
Although specific risk factors for progression to DN have been identified for
T2DM patients as a whole, these factors do not reliably predict progression in
individual patients. Currently available clinical indicators of kidney disease
(e.g., elevated serum creatinine and microalbuminuria) lack the sensitivity
and/or specificity to identify early-stage DN.Thus, more robust non-invasive
screening tools are needed to detect early-stage DN prior to development of
significant irreversible renal injury, when potential therapeutics/interventions
may be most effective. Diffusion tensor imaging (DTI) is a quantitative
diffusion Magnetic Resonance Imaging (MRI) technique that measures both the
magnitude and directionality of water movement (fractional anisotropy, FA) to
assess pathophysiologic changes. Preliminary data suggest that decreased
medullary FA may be a biomarker for early DN, but additional studies are
needed.The overall goals of the proposed pilot studies are to utilize DTI-MRI
and a related imaging modality, IVIM, to obtain data necessary to design and
implement a longitudinal study of medullary FA as a biomarker for early DN and
to determine whether decreased medullary FA is due to changes in tubular
microstructure or medullary perfusion. The hypotheses is that T2DM patients with
apparently intact renal function will have a lower mean medullary FA and greater
variance of medullary FA compared matched controls, suggesting the presence of a
subset at risk for progression to DN and that low medullary FA results from
changes in renal microstructure. Specific aims are: (1) To assess renal
medullary FA in T2DM subjects without clinical evidence of renal disease vs.
healthy controls; and (2)To define the mechanism underlying medullary FA changes
in DN. Twenty-four (12M/12F) T2DM subjects, 40-60 years of age with eGFR
(>80ml/min/1.73m2), no albuminuria and 5-10 years duration of T2DM will undergo
DTI-MRI and IVIM scanning and results compared to 16 (8M/8F) age, race, gender
and BMI-matched controls.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 25848
Supply Total Costs 0
Equipment Total Costs 0
Travel/Other Total Costs 31600
Direct Costs 57448
Indirect Costs Proposed 33607
Total Costs Proposed 91055
Total Costs Approved 91055
Start Date 10/1/2014
End Date 9/30/2015
IFO Name Lipkovich, Holly
IFO E-Mail Address medrespre@case.edu
IACUC/IRB No. 12-00236
IACUC/IRB Institution Case Western Reserve
Entity ID No. FWA000004428
Report Request Date 10/30/2015
T1D NO
TypeCount
Invoices 7
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  14GHSU137725732-55Case Western Reserve7/29/2015$10,187.69-$10,187.69$32,908.46View PDF
  View  14GHSU137725732-55Case Western Reserve6/29/2016$13,211.97$7,729.00$20,940.97$32,908.46View PDF
  View  14GHSU137725732-55Case Western Reserve4/30/2015$7,621.74-$7,621.74$32,908.46View PDF
  View  14GHSU137725732-55Case Western Reserve4/21/2016$1,609.67$941.66$2,551.33$32,908.46View PDF
  View  14GHSU137725732-55Case Western Reserve3/17/2016$4,789.04$2,801.60$7,590.64$32,908.46View PDF
  View  14GHSU137725732-55Case Western Reserve2/4/2015$3,545.43-$3,545.43$32,908.46View PDF
  View  14GHSU137725732-55Case Western Reserve10/21/2015$5,708.74-$5,708.74$32,908.46View PDF


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