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Reprogramming human adult renal cells for kidney regeneration
Summary Data Summary
Applicant DEKEL, BENJAMIN
E-Mail Address binyamin.dekel@sheba.health.gov.il
Project Title Reprogramming human adult renal cells for kidney regeneration
CBU ID 14GHSU1381
External SubContract ID 25732-64
Diabetic Complication Nephropathy
Funding Program Group Pilot & Feasibility [PF2014]
Abstract As dialysis and kidney transplantation are currently the only successful
therapies for patients suffering from end stage renal disease, and these
approaches are limited by patient morbidity and organ shortages, cell therapy
with renal stem/progenitor cells may offer an alternative approach for treatment
of renal diseases.
The nephron, the kidney's functional unit, arises during development from a self
renewing pool of multipotent nephron forming cells. This population becomes
extinguished shortly after birth in the mouse and at the 34-week of human
gestation, rendering the postnatal kidney unable to regenerate new nephrons in
response to
kidney injury.
Reprogramming of adult kidney cells backwards into early multipotent nephron
forming cells that can be grown in culture are a crucial to neo-nephrogenesis,
kidney regeneration and kidney engineering. Preliminary data from our labs
suggests that ectopic expression in adult kidney cells of pluripotent factors
such as LIN28 and OCT4 and nephrogenic factors such as OSR1, SIX2, PAX2 might
lead to reprogramming of these cells into early kidney progenitors, and thus, to
a new source of nephron forming cells. Our data suggest that none of these
factors alone leads to a multi-potent state. In this project we propose to
further study the role of each of these genes in renal reprogramming, and then
to define the ideal combination of pluripotent and nephrogenic factors required
for reprogramming of adult kidney cells into expandable and functional 鈥渋nduced
Nephron-Forming鈥 (iNF) cells. Success in deriving iNF cells promises to have a
revolutionary impact on the field of renal medicine.to have a revolutionary
impact on the field of renal medicine.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 50400
Supply Total Costs 36550
Equipment Total Costs 0
Travel/Other Total Costs 0
Direct Costs 86950
Indirect Costs Proposed 13042
Total Costs Proposed 99992
Total Costs Approved 100000
Start Date 10/1/2014
End Date 9/30/2015
IFO Name
IFO E-Mail Address
IACUC/IRB No. 999999
IACUC/IRB Institution Sheba Medical Center
Entity ID No.
Report Request Date 10/30/2015
T1D NO
TypeCount
Invoices 3
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  14GHSU138125732-64Sheba Medical Center5/20/2015$4,458.00-$4,458.00$8.00View PDF
  View  14GHSU138125732-64Sheba Medical Center3/31/2015$16,197.00-$16,197.00$8.00View PDF
  View  14GHSU138125732-64Sheba Medical Center11/18/2015$79,337.00-$79,337.00$8.00View PDF


Reports
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