¿´Æ¬ÊÓƵ

Object moved to here.

¿´Æ¬ÊÓƵ :: Pilot & Feasibility Program Application

¿´Æ¬ÊÓƵ


Reactive lipids in podocyte homeostasis
Summary Data Summary
Applicant Stadler, Krisztian
E-Mail Address krisztian.stadler@pbrc.edu
Project Title Reactive lipids in podocyte homeostasis
CBU ID 14GHSU1393
External SubContract ID 25732-49
Diabetic Complication Nephropathy
Funding Program Group Pilot & Feasibility [PF2014]
Abstract Early podocyte loss is characteristic of chronic kidney diseases, edpecially in
diabetes and metabolic syndrome related nephropathies. Changes in the redox
environment and redox imbalance have been implicated to play a role in podocyte
loss, but the mechanisms are not well known. Reactive lipids and their
end-products are an established biomarker in human diabetes, but it is not known
how reactive lipids may influence podocyte homeostasis. The goal of our proposal
is to understand the role of these reactive lipids in modulating podocyte
survival signaling. The long term aim is to establish a role for these reactive
species in the development of chronic kidney disesase and nephropathy. We have
compelling preliminary data to propose that lipid radicals may fine tune
podocyte response on an adaptive to maladaptive scale. While low levels of
reactive lipids activate prosurvival mechanisms, higher levels may lead to
pathology. The mechanisms involve redox sensitive control of rhoA to regulate
podocyte motility and cytoskeletal rearrangements, and triggers to the slit
diaphragm proteins - Akt axis to modulate survival signaling. To test this
hypothesis, we will use in vitro and in vivo experiments, combined with our
state of the art free radical approaches. In Aim 1, we will determine that
reactive lipids serve as redox instigators of rhoA and survival mechanisms
through Akt and podocyte specific proteins. In Aim 2, we will establish that
specific scavenging of excess lipid radicals restores adaptive redox signaling
in podocytes in vivo. Collectively, these aims will answer an important question
- how lipid radicals may trigger podocyte survival or death and therefore how
they contribute to podocyte defects and albuminuria. Outcomes from this proposal
will advance the field by offering new avenues to targeted, redox based
therapies, through understanding the mechanisms modulated by reactive lipids in
podocytes.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 30627
Supply Total Costs 20000
Equipment Total Costs 0
Travel/Other Total Costs 3918
Direct Costs 54545
Indirect Costs Proposed 5455
Total Costs Proposed 60000
Total Costs Approved 60000
Start Date 10/1/2014
End Date 9/30/2015
IFO Name LaVergne, Guy
IFO E-Mail Address grants@pbrc.edu
IACUC/IRB No. 999999
IACUC/IRB Institution Pennington Biomedical Research Center
Entity ID No. 172-6000848B7
Report Request Date 10/30/2015
T1D NO
TypeCount
Invoices 12
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  14GHSU139325732-49Pennington Biomedical Research Center9/11/2015$11,506.74-$11,506.74$1,443.29View PDF
  View  14GHSU139325732-49Pennington Biomedical Research Center8/10/2015$11,506.74-$11,506.74$1,443.29View PDF
  View  14GHSU139325732-49Pennington Biomedical Research Center7/14/2015$141.74-$141.74$1,443.29View PDF
  View  14GHSU139325732-49Pennington Biomedical Research Center7/13/2016$4,623.80$462.41$5,086.21$1,443.29View PDF
  View  14GHSU139325732-49Pennington Biomedical Research Center6/9/2016$3,013.57$301.37$3,314.94$1,443.29View PDF
  View  14GHSU139325732-49Pennington Biomedical Research Center6/9/2015$4,755.57-$4,755.57$1,443.29View PDF
  View  14GHSU139325732-49Pennington Biomedical Research Center5/12/2016$2,273.35$227.42$2,500.77$1,443.29View PDF
  View  14GHSU139325732-49Pennington Biomedical Research Center4/11/2016$4,152.30$415.25$4,567.55$1,443.29View PDF
  View  14GHSU139325732-49Pennington Biomedical Research Center12/15/2015$171.60-$171.60$1,443.29View PDF
  View  14GHSU139325732-49Pennington Biomedical Research Center12/11/2015$393.36-$393.36$1,443.29View PDF
  View  14GHSU139325732-49Pennington Biomedical Research Center11/20/2015$12,476.94-$12,476.94$1,443.29View PDF
  View  14GHSU139325732-49Pennington Biomedical Research Center10/31/2016$1,940.50$194.05$2,134.55$1,443.29View PDF
Click here to cancel and return to funding program application

*Author:
*SubContract:
*Select File:

Click browse and select the file to upload.
(Please upload ONLY TXT, Image Files (not histolgy), PDF, XLS, XLSX, DOC, or DOCX files.)