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Novel Regulators of Diet-Mediated Nephrocyte Dysfunction in Drosophila
Summary Data Summary
Applicant Cagan, Ross
E-Mail Address ross.cagan@mssm.edu
Project Title Novel Regulators of Diet-Mediated Nephrocyte Dysfunction in Drosophila
CBU ID 14GHSU1396
External SubContract ID 25034-56
Diabetic Complication Nephropathy
Funding Program Group Pilot & Feasibility [PF2014]
Abstract Diabetic nephropathy is a complex disease with effects on the renal system and,
appreciated more recently, the glomerular system including the podocyte.
Podocyte foot effacement and substantial molecular changes occur in T2DM
patients, leading to progressive loss of filtration and cell shedding that
initiate early in disease progression. These defects are due to disruption of
the glomerular basement membrane and/or disruption of the slit diaphragm,
filtering structures associated with the podocytes.

Recently we have found evidence for a pathway in flies that links elevated
dietary sugar to reduced expression of Sns, a fly ortholog of the slit diaphragm
protein Nephrin. We have partly validated our results in mammalian models. Loss
of Sns—analogous to loss of Nephrin—led to dysfunction of the nephrocyte, a
group of cells analogous to our own glomerulus. We have established a 'core
pathway' that links dietary sugar to reduction of Sns and Nephrin.

Here we expand our efforts, exploring pathways that link high dietary sugar to
loss Sns. We will use deficiencies in a genetic approach to identifying novel
regulators and expanding our recently identified core pathway.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 38752
Supply Total Costs 20245
Equipment Total Costs 0
Travel/Other Total Costs 0
Direct Costs 58997
Indirect Costs Proposed 41003
Total Costs Proposed 100000
Total Costs Approved 100000
Start Date 10/1/2014
End Date 9/30/2015
IFO Name Harvey, Stephen
IFO E-Mail Address Stephen.Harvey@mountsinai.org
IACUC/IRB No. 999999
IACUC/IRB Institution Mount Sinai School of Medicine
Entity ID No.
Report Request Date 10/30/2015
T1D NO
TypeCount
Invoices 3
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  14GHSU139625034-56Mount Sinai School of Medicine2/20/2015$17,030.40-$17,030.40-View PDF
  View  14GHSU139625034-56Mount Sinai School of Medicine11/5/2015$49,591.74-$49,591.74-View PDF
  View  14GHSU139625034-56Mount Sinai School of Medicine11/25/2015$33,377.86-$33,377.86-View PDF


Reports
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