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Model of acute painful diabetic neuropathy after rapid glycemic control
Summary Data Summary
Applicant Jolivalt, Corinne
E-Mail Address cjolivalt@ucsd.edu
Project Title Model of acute painful diabetic neuropathy after rapid glycemic control
CBU ID 15GHSU1482
External SubContract ID 25034-73
Diabetic Complication Neuropathy & Neurocognition
Funding Program Group Pilot & Feasibility [PF2015]
Abstract Acute painful diabetic neuropathy of rapid glycemic control (APDNRGC) is an
acute and severe form of neuropathic pain, distinct from chronic neuropathic
pain that afflict diabetic patients. APDNRGC develop after rapid glycemic
control in both type 1 and type 2 diabetes. The pain may be sensitivity to
temperature (thermal hyperalgesia) and/or touch (tactile allodynia), persists
for months to years and rather resistant to conventional diabetic neuropathy
treatment (Caravati, 1933, Tesfaye et al., 1996, Dabby et al., 2009, Gibbons and
Freeman, 2010). The pathophysiology of APDNRGC is uncertain due to the lack of
mechanistic knowledge resulting from the lack of animal models. This has
precluded development of any therapy that could mitigate this debilitating
condition. We have found that the insulin receptors are sensitized in diabetic
rat sciatic nerve and that systemic insulin given to type 1 diabetic mice causes
tactile allodynia within 60 min and persisted for at least 3 hours. In this
proposal, we will develop and characterize a model of ADPNRGC for type 1
diabetes in order to understand the mechanism leading to this acute but
persistent pain. We hypothesize that direct effects of insulin on peripheral
nerve insulin receptors contribute to this condition. With this proposal, we aim
at elucidating the pathogenic mechanisms for ADPNRGC, providing an avenue for
effective therapies development.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 35493
Supply Total Costs 2700
Equipment Total Costs 0
Travel/Other Total Costs 517
Direct Costs 38710
Indirect Costs Proposed 21290
Total Costs Proposed 60000
Total Costs Approved 54000
Start Date 10/1/2015
End Date 9/30/2016
IFO Name Cooper, Mark
IFO E-Mail Address mecooper@ucsd.edu
IACUC/IRB No. S13141
IACUC/IRB Institution The Regents of the Univ. of Calif., U.C. San Diego
Entity ID No. 95-6006-144
Report Request Date 10/30/2016
T1D NO
TypeCount
Invoices 7
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  15GHSU148225034-73The Regents of the Univ. of Calif., U.C. San Diego9/4/2016$1,645.00$904.75$2,549.75$41,439.57View PDF
  View  15GHSU148225034-73The Regents of the Univ. of Calif., U.C. San Diego7/20/2016$1,698.08$933.95$2,632.03$41,439.57View PDF
  View  15GHSU148225034-73The Regents of the Univ. of Calif., U.C. San Diego6/6/2016$1,232.96$678.13$1,911.09$41,439.57View PDF
  View  15GHSU148225034-73The Regents of the Univ. of Calif., U.C. San Diego5/9/2016$894.88$492.18$1,387.06$41,439.57 
  View  15GHSU148225034-73The Regents of the Univ. of Calif., U.C. San Diego4/11/2016$1,059.55$582.75$1,642.30$41,439.57View PDF
  View  15GHSU148225034-73The Regents of the Univ. of Calif., U.C. San Diego3/9/2016$1,517.36$834.54$2,351.90$41,439.57View PDF
  View  15GHSU148225034-73The Regents of the Univ. of Calif., U.C. San Diego2/9/2016$86.30-$86.30$41,439.57View PDF
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