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Cross-Species Systems Biology of Diabetic Nephropathy
Summary Data Summary
Applicant Kretzler, Matthias
E-Mail Address kretzler@umich.edu
Project Title Cross-Species Systems Biology of Diabetic Nephropathy
CBU ID 11GHSU154
External SubContract ID 25034-3
Diabetic Complication Nephropathy
Funding Program Group Pilot & Feasibility [PF2011]
Abstract Diabetic nephropathy (DN) is an endorgan complication responsible for
significant morbidity and mortality in type 1 and type 2 diabetes mellitus.
Association of genes and gene products with DN are currently defined in humans
using genome wide association studies and renal tissue based gene expression
studies. However, animal models are instrumental to define the functional impact
of the associated molecules. The AMDCC has established an extensive data set
defining the framework for DN in mice. A crucial next step will be to integrate
the murine molecular information with corresponding comprehensive human data
sets.
We have developed and employed a webbased analysis engine, Nephromine, for
integrated systems biology analysis of renal gene expression for the renal
research community. Nephromine accesses highly annotated human renal gene
expression datasets in multiple search modes (see tutorial at nephromine.org),
though Nephromine has been limited to human datasets to date. The goal of this
application is to integrate murine DN gene expression data sets generated by the
AMDCC and the renal research community at large with the human DN data sets to
define shared and specific mechanism between mouse and man.
Specific aims to be addressed are:
Aim 1. Identify and annonate murine gene expression data sets of DN from AMDCC
data repository, Gene Expression Omnibuts (GEO) and those accessed by direct
interaction with investigative teams.
Aim 2. Compare murine DN gene expression data sets with human DN data sets and
identify shared transcriptional changes on a network level.
Aim 3. Upload murine data sets into Nephromine for human-mouse comparative
analysis by the renal research community.
Comparing the renal transcriptiome of human DN to the carefully characterized
AMDCC murine DN models will allow the renal research community to define
molecular mechanism shared between mouse and man. With this information,
investigators will be able to select the murine models that recapitulate the
human disease mechanisms to be interrogated in their murine experimental
studies. Defining mouse models a priori for their ability to recapitulate human
disease will be a crucial step to increase comparability of murine studies to
human disease mechanisms. This will aid in defining novel therapeutic targets
for their efficacy in the specific murine models of DN and should decrease the
attrition rate of compounds with activity in murine DN in their further
validation as therapeutic targets of human DN.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 57577
Supply Total Costs 0
Equipment Total Costs 0
Travel/Other Total Costs 6732
Direct Costs 64309
Indirect Costs Proposed 35691
Total Costs Proposed 100000
Total Costs Approved 100000
Start Date 9/1/2011
End Date 12/31/2012
IFO Name Madden, Thomas
IFO E-Mail Address thommad@umich.edu
IACUC/IRB No. 999999
IACUC/IRB Institution University of Michigan
Entity ID No. 38-6006309
Report Request Date 1/31/2013
T1D NO
TypeCount
Invoices 10
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  11GHSU15425034-3University of Michigan8/6/2012$4,515.82$2,506.28$7,022.10$7,022.10 
  View  11GHSU15425034-3University of Michigan7/6/2012$4,514.11$2,505.33$7,019.44$7,022.10 
  View  11GHSU15425034-3University of Michigan6/8/2012$4,514.01$2,505.28$7,019.29$7,022.10 
  View  11GHSU15425034-3University of Michigan5/8/2012$5,917.14$3,284.01$9,201.15$7,022.10 
  View  11GHSU15425034-3University of Michigan4/9/2012$4,514.00$2,505.27$7,019.27$7,022.10 
  View  11GHSU15425034-3University of Michigan3/9/2013$11,509.42$6,387.73$17,897.15$7,022.10View PDF
  View  11GHSU15425034-3University of Michigan3/7/2012$3,959.59$2,197.57$6,157.16$7,022.10 
  View  11GHSU15425034-3University of Michigan2/8/2012$4,514.00$2,505.27$7,019.27$7,022.10 
  View  11GHSU15425034-3University of Michigan12/6/2011$12,678.75$7,036.71$19,715.46$7,022.10 
  View  11GHSU15425034-3University of Michigan1/10/2012$3,156.02$1,751.59$4,907.61$7,022.10 
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