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The role of intestinal dysbiosis in diabetic nephropathy
Summary Data Summary
Applicant Smith, Kelly
E-Mail Address kelsmith@uw.edu
Project Title The role of intestinal dysbiosis in diabetic nephropathy
CBU ID 12GHSU185
External SubContract ID 25034-14
Diabetic Complication Nephropathy
Funding Program Group Pilot & Feasibility [PF2012]
Abstract Obesity and metabolic syndrome are leading causes of type II diabetes, which is
a growing epidemic and one of the major global health problems that we face in
the 21st century. Obesity and diabetes are associated with an altered gut
microbiota that further aggravates metabolic syndrome, and may promote
inflammation and contribute to diabetic complications. The focus of this grant
application is the role of the microbiome in modulating complications of
diabetes. My collaborator, Charles Alpers (University of Washington), has
recently characterized a new mouse model of type II diabetes, which develops
several diabetic complications, notably diabetic nephropathy, as well as
cardiomyopathy and potential retinopathy. The BTBRob/ob mouse is leptin
deficient, resulting in progressive obesity and type II diabetes. The novel
aspect of this mouse model of type II diabetes is that these mice also develop
clinical and morphologic features that closely mimic diabetic nephropathy in
humans. Thus this model provides a tool to dissect factors that contribute not
only to the development of insulin resistance and diabetes, but also end organ
damage and specifically, diabetic nephropathy. Hypothesis: Studies with obese
mice and humans indicate that these individuals have an altered microbiome, and
that this altered microbiome can promote obesity, fatty liver disease, and
diabetes. Similarly, diabetes is associated with changes in the microbiome in
rodent models. We hypothesize that genetic obesity and diabetes cause changes in
the gut microbiota (intestinal dysbiosis) that contribute to complications of
diabetes. We will test our hypothesis with the following specific Aims. Specific
Aim 1: To characterize the microbiome, and whether there is evidence of
increased translocation and exposure to gut microbes in diabetic mice. Specific
Aim 2: To determine whether BTBRob/ob mice have a diabetogenic microbiome that
contributes to the development of diabetic nephropathy.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 28817
Supply Total Costs 7500
Equipment Total Costs 0
Travel/Other Total Costs 18223
Direct Costs 54540
Indirect Costs Proposed 5454
Total Costs Proposed 59994
Total Costs Approved 59994
Start Date 10/1/2012
End Date 3/31/2014
IFO Name DeFries, Kirsten
IFO E-Mail Address kirsten5@u.washington.edu
IACUC/IRB No. 999999
IACUC/IRB Institution University of Washington
Entity ID No. 91-6001537
Report Request Date 1/1/3000
T1D NO
TypeCount
Invoices 16
Progress Reports 0
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  12GHSU18525034-14University of Washington9/10/2013$2,862.40$286.25$3,148.65-View PDF
  View  12GHSU18525034-14University of Washington8/9/2013$3,002.78$300.28$3,303.06-View PDF
  View  12GHSU18525034-14University of Washington7/10/2013$3,159.34$315.93$3,475.27-View PDF
  View  12GHSU18525034-14University of Washington6/10/2013$2,881.64$288.16$3,169.80-View PDF
  View  12GHSU18525034-14University of Washington5/10/2013$3,000.85$300.08$3,300.93-View PDF
  View  12GHSU18525034-14University of Washington4/9/2014$783.01$78.31$861.32-View PDF
  View  12GHSU18525034-14University of Washington4/10/2013$3,149.08$314.90$3,463.98-View PDF
  View  12GHSU18525034-14University of Washington3/11/2014$2,127.36$212.74$2,340.10-View PDF
  View  12GHSU18525034-14University of Washington3/11/2013$4,394.87$439.48$4,834.35-View PDF
  View  12GHSU18525034-14University of Washington2/11/2014$2,123.26$212.33$2,335.59-View PDF
  View  12GHSU18525034-14University of Washington2/11/2013$3,040.16$304.01$3,344.17-View PDF
  View  12GHSU18525034-14University of Washington12/10/2013$7,968.16$796.82$8,764.98-View PDF
  View  12GHSU18525034-14University of Washington11/12/2013$4,331.47$433.15$4,764.62-View PDF
  View  12GHSU18525034-14University of Washington10/10/2013$3,994.44$399.45$4,393.89-View PDF
  View  12GHSU18525034-14University of Washington1/9/2014$3,979.16$397.92$4,377.08-View PDF
  View  12GHSU18525034-14University of Washington1/9/2013$3,742.01$374.20$4,116.21-View PDF
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