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Development of a Biobank of Human Diabetic Nephropathy
Summary Data Summary
Applicant Fogo, Agnes
E-Mail Address agnes.fogo@vanderbilt.edu
Project Title Development of a Biobank of Human Diabetic Nephropathy
CBU ID 12GHSU208
External SubContract ID 25034-21
Diabetic Complication Nephropathy
Funding Program Group Pilot & Feasibility [PF2012]
Abstract Diabetic nephropathy is the leading cause of chronic kidney disease, and is
increasing both in the US and worldwide. There is lack of knowledge of the range
of lesions that may develop in diabetic patients who do not present with the
atypical features that result in renal biopsy. In the modern era of ACE
inhibitor treatment, there is limited information on the structural changes that
occur in diabetic patients with or without diagnosed nephropathy except for rare
protocol biopsies related to entry points for clinical trials, and classic
autopsy studies. Further, application of novel methods of analysis, including
non-biased proteomic approaches, linked to sophisticated and detailed
morphologic and morphometric analyses, with linkage to functional changes in
patients, is lacking. However, it is not feasible or ethical to biopsy diabetic
patients where there is no clinical indication and they are not part of a
clinical trial.
In this pilot project, we propose a novel strategy to bridge this gap in
knowledge, by developing a system that will allow allocation of portions of
tissue obtained from tumor nephrectomy specimens and at autopsy, and then
linking these samples to a de-identified electronic medical record (EMR). This
pilot will build on the existing BioVU project, which currently links blood DNA
samples to patient de-identified synthetic EMRs. The availability of this tissue
along with the DNA from diabetic and non-diabetic patients who opt into the
BioVU system will provide detailed longitudinal clinical data and will provide
an exceptional tool for such dedicated studies over the course of diabetic
nephropathy and in diabetic patients without overt nephropathy and in
non-diabetic patients as controls. Furthermore, any correlations of phenotypic
and genomic signals obtained from these samples can be further queried using the
repository of existing DNA samples of patients carrying the diagnosis of
diabetic nephropathy in the BioVU repository. Thus, our pilot study will test
feasibility of this approach, with potential to create an exceptional data bank
of a variety of tissues remaining from various surgical pathology specimens and
at autopsy.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 10063
Supply Total Costs 2625
Equipment Total Costs 4000
Travel/Other Total Costs 23209
Direct Costs 39897
Indirect Costs Proposed 20103
Total Costs Proposed 60000
Total Costs Approved 60000
Start Date 10/1/2012
End Date 9/30/2013
IFO Name Todd, Steve
IFO E-Mail Address steve.todd@vanderbilt.edu
IACUC/IRB No. 99999
IACUC/IRB Institution Vanderbilt University
Entity ID No. 1620476822A2
Report Request Date 10/30/2014
T1D NO
TypeCount
Invoices 23
Progress Reports 2
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  12GHSU20825034-21Vanderbilt University9/9/2013$848.39$475.10$1,323.49$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University9/8/2014$2,241.32-$2,241.32$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University8/13/2013$848.39$475.10$1,323.49$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University8/11/2014$2,749.65-$2,749.65$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University7/17/2014$1,559.59-$1,559.59$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University7/17/2013$1,502.62$841.47$2,344.09$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University6/9/2014$1,330.46-$1,330.46$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University6/13/2013$834.98$467.59$1,302.57$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University5/8/2014$1,631.15-$1,631.15$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University5/10/2013$501.16$280.65$781.81$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University4/28/2015$799.01-$799.01$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University4/11/2013$501.16$280.65$781.81$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University4/10/2014$4,944.25-$4,944.25$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University3/11/2013$501.16$280.65$781.81$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University3/10/2014$905.61$507.14$1,412.75$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University2/27/2013$501.16$280.65$781.81$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University2/10/2014$1,040.61$582.74$1,623.35$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University12/10/2013$848.39$475.10$1,323.49$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University11/11/2013$4,905.39$533.90$5,439.29$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University11/10/2014$7,756.63-$7,756.63$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University10/7/2014$6,770.77-$6,770.77$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University10/10/2013$848.39$475.10$1,323.49$1,096.40View PDF
  View  12GHSU20825034-21Vanderbilt University1/9/2014$5,498.41$3,079.11$8,577.52$1,096.40View PDF
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