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Intermittent Hypoxia and Urologic Complications of Diabetes
Summary Data Summary
Applicant Vezina, Chad
E-Mail Address cmvezina@wisc.edu
Project Title Intermittent Hypoxia and Urologic Complications of Diabetes
CBU ID 13GHSU246
External SubContract ID 25034-30
Diabetic Complication Uropathy
Funding Program Group Pilot & Feasibility [PF2013]
Abstract Persons with type 2 diabetes have a high risk of developing bothersome lower
urinary tract symptoms (LUTS), including incomplete emptying, urinary frequency,
urgency and incontinence. These urinary symptoms impair quality of life and are
costly to manage, especially since most type 2 diabetic patients seeking
treatment for LUTS require lifetime therapy for their urinary symptoms.
Prolonged treatment is necessary because few LUTS are cured by existing
therapies. Effective treatments for LUTS are lacking because the underlying
basis of most urinary symptoms is not known at this time.

The risk of developing bothersome lower urinary tract symptoms is increased in
patients experiencing obstructive sleep apnea, which exists in as many as 87% of
type 2 diabetic patients. This pilot study is the first of a series of studies
to test the hypothesis that physiological manifestations of sleep apnea underlie
urinary complications in many type 2 diabetic patients. One physiological
hallmark of obstructive sleep apnea is intermittent hypoxia. We will test
whether intermittent hypoxia is sufficient to alter voiding behavior and bladder
physiology in mice and whether intermittent hypoxia also causes further
deterioration of lower urinary tract function when combined with type 2
diabetes. We will use an innovative custom-designed, computer-controlled chamber
to achieve specific patterns of inspired oxygen in order to isolate and test the
variable of intermittent hypoxia on urinary function in diabetic mice. We will
use BTBR-wild type mice and BTBR.V(B6)-Lepob/WiscJ (BTBR ob/ob) mice that harbor
a spontaneous mutation in the leptin gene and progressively develop obesity,
hyperglycemia, and insulin resistance. Urinary function will be assessed in wild
type and mutant mouse strains following normoxia or chronic intermittent hypoxia
exposures. We expect to reveal intermittent hypoxia as an underlying contributor
to lower urinary tract symptoms. These results will drive the design of future
studies, which will incorporate one of the world’s largest population-based
prospective studies on sleep disordered breathing and health, to determine
whether sleep studies are warranted for type 2 diabetics with lower urinary
tract symptoms.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 28190
Supply Total Costs 8000
Equipment Total Costs 7000
Travel/Other Total Costs 0
Direct Costs 43190
Indirect Costs Proposed 21811
Total Costs Proposed 65001
Total Costs Approved 65001
Start Date 10/1/2013
End Date 9/30/2014
IFO Name Moreland, Kim
IFO E-Mail Address preaward@rsp.wisc.edu
IACUC/IRB No. 9999
IACUC/IRB Institution University of Wisconsin-Madison
Entity ID No. 1612021220000
Report Request Date 10/30/2014
T1D NO
TypeCount
Invoices 9
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  13GHSU24625034-30University of Wisconsin-Madison9/3/2014$9,105.68-$9,105.68$0.01View PDF
  View  13GHSU24625034-30University of Wisconsin-Madison8/4/2014$8,806.67-$8,806.67$0.01View PDF
  View  13GHSU24625034-30University of Wisconsin-Madison7/2/2014$9,929.09-$9,929.09$0.01View PDF
  View  13GHSU24625034-30University of Wisconsin-Madison6/3/2014$9,741.00-$9,741.00$0.01View PDF
  View  13GHSU24625034-30University of Wisconsin-Madison5/2/2014$9,457.47-$9,457.47$0.01View PDF
  View  13GHSU24625034-30University of Wisconsin-Madison4/2/2014$2,929.80-$2,929.80$0.01View PDF
  View  13GHSU24625034-30University of Wisconsin-Madison3/4/2014$3,391.17$1,712.54$5,103.71$0.01View PDF
  View  13GHSU24625034-30University of Wisconsin-Madison2/4/2014$79.77$40.28$120.05$0.01View PDF
  View  13GHSU24625034-30University of Wisconsin-Madison11/26/2014$9,807.52-$9,807.52$0.01View PDF


Reports
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