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Impact of Diabetes on Urothelial Progenitor Cell Function and Healing
Summary Data Summary
Applicant Colopy, Sara
E-Mail Address colopys@svm.vetmed.wisc.edu
Project Title Impact of Diabetes on Urothelial Progenitor Cell Function and Healing
CBU ID 15GHSU2515
External SubContract ID 25034-67
Diabetic Complication Uropathy
Funding Program Group Pilot & Feasibility [PF2015]
Abstract Recurrent urinary tract infections (UTIs) have a profoundly negative impact on
quality of life in diabeticwomen. Up to 50% of diabetic women will develop a
UTI, which is twice as high as non-diabetic women.Further, diabetic women have a
two-fold higher risk of suffering from recurrent UTIs throughout their
lifetime.Patients with diabetes are more prone to developing severe
manifestations of UTI, including gas-forming(emphysematous) cystitis, kidney
infections, and death. There remains an absence of targeted treatmentstrategies
to decrease the incidence of UTI in diabetic patients largely because the
underlying basis for theincreased risk of UTI in diabetic patients is not known.
As such, diabetic women are treated with chronicantibiotics, leading to
substantial economic burden as well as an increase in multidrug-resistant
UTIs.Paramount to UTI prevention is maintenance of the complex urothelial
barrier that lines the bladder lumen.Diabetes causes impaired progenitor cell
function and wound healing in many organs, raising the possibilitythat diabetes
affects urothelial progenitors as well. It is our overarching hypothesis that
diabetes causesimpaired urothelial progenitor cell function and regeneration,
loss of barrier function, and increased risk for UTI. This pilot project will
test the specific hypothesis that diabetes results in loss of urothelial
progenitor cellfunction and impaired urothelial regeneration after treatment of
UTI. We will test this hypothesis using twomouse models of type II diabetes:
BTBR ob/ob mice and high-fat diet (HFD)-induced diabetic mice. In Aim 1,we will
test the hypothesis that urothelial regeneration after treatment of UTI is
impaired in BTBR ob/ob micecompared to BTBR wild-type (WT) mice. In Aim 2, we
will test the hypothesis that urothelial progenitor cellfunction is impaired in
diabetic mice compared to non-diabetic mice. This proposal employs
amultidisciplinary team science approach to study the impact of diabetes on
urothelial progenitor cell functionand regeneration. We anticipate that these
studies will produce clinically relevant data that can be used as astarting
point to evaluate the effects and causes of recurrent UTI in human diabetic
patients.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 8736
Supply Total Costs 6000
Equipment Total Costs 0
Travel/Other Total Costs 24280
Direct Costs 39016
Indirect Costs Proposed 20678.48
Total Costs Proposed 59694.48
Total Costs Approved 59694
Start Date 10/1/2015
End Date 7/31/2017
IFO Name Egan, Brenda
IFO E-Mail Address preaward@resp.wisc.edu
IACUC/IRB No. V00916-0-03-14
IACUC/IRB Institution University of Wisconsin-Madison
Entity ID No. 396006492
Report Request Date 1/1/3000
T1D NO
TypeCount
Invoices 5
Progress Reports 0
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  15GHSU251525034-67University of Wisconsin-Madison8/25/2016$2,197.08$1,164.45$3,361.53$23,764.69View PDF
  View  15GHSU251525034-67University of Wisconsin-Madison7/5/2017$13,897.79$7,365.83$21,263.62$23,764.69View PDF
  View  15GHSU251525034-67University of Wisconsin-Madison7/5/2016$1,954.96$1,036.12$2,991.08$23,764.69View PDF
  View  15GHSU251525034-67University of Wisconsin-Madison6/3/2016$1,745.24$924.97$2,670.21$23,764.69View PDF
  View  15GHSU251525034-67University of Wisconsin-Madison10/27/2016$3,688.15$1,954.72$5,642.87$23,764.69View PDF
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