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Comparative Transcriptomics to Identify Key Gene Networks of Diabetic Neuropathy

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Data Summary

Applicant	Hur, Junguk
E-Mail Address	junguk.hur@med.und.edu
Project Title	Comparative Transcriptomics to Identify Key Gene Networks of Diabetic Neuropathy
CBU ID	15GHSU2517
External SubContract ID	25034-75
Diabetic Complication	Neuropathy & Neurocognition
Funding Program Group	Pilot & Feasibility [PF2015]
Abstract	Diabetes currently affects 29 million Americans, and the incidence is increasing by 5% per year. Diabetic peripheral neuropathy (DPN), the most common complication of diabetes, occurs in approximately 60% of all diabetic subjects. DPN is the leading cause of diabetes-related hospital admissions and non-traumatic amputations in the United States, there is substantial irreparable nerve damage prior to the development of noticeable symptoms. However, there are currently no disease-modifying treatments available for DPN other than glycemic control and symptomatic treatments for pain. Therefore, there is a critical need to identify novel effective therapies for DPN. The overall objectives of this proposal is (1) to identify crucial genes and pathways that underlie the progression of human DPN, and (2) to identify commonly dysregulated critical pathways in both human DPN and animal models of DPN. The rationale for the proposed research is that the identification of shared critical pathways and gene expression signatures between human and mouse DPN will elucidate the core mechanisms of DPN progression and expedite the development of mechanism-based therapeutic agents. We will accomplish the objectives of this proposal by pursuing the following specific aims: Aim 1. Identify dysregulated genes and pathways in human DPN using RNA-Seq. We previously reported that there are distinctive groups of human subjects with regenerative, stable, or degenerative DPN. We will use RNA-Seq to compare the transcriptomic signatures in sural nerves biopsies from subjects with regenerative DPN to subjects with degenerative DPN. Aim 2. Identify commonly dysregulated DPN-associated genes and pathways across species. We will compare the transcriptional regulatory network in human DPN with those identified in various mouse DPN models to provide insight into common pathways underlying DPN across species. We anticipate that the key genes and pathways highly correlated with DPN progression and conserved across species will play crucial roles in the pathogenesis of DPN and serve as primary targets of therapeutic intervention of DPN.
Application PDF	Application Research Plan
Status	Contract Executed
Key Personnel
Salary Total Costs	29442
Supply Total Costs	1847
Equipment Total Costs	0
Travel/Other Total Costs	40500
Direct Costs	71789
Indirect Costs Proposed	27697
Total Costs Proposed	99486
Total Costs Approved	89537
Start Date	10/1/2015
End Date	1/31/2017
IFO Name	Horner, Sally
IFO E-Mail Address	sally.horner@research.und.edu
IACUC/IRB No.	99999
IACUC/IRB Institution	University of North Dakota
Entity ID No.
Report Request Date	2/28/2017
T1D	NO

Type	Count
Invoices	2
Progress Reports	2

Data Submission

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Url	CBU ID	External ID	Institution	Date	Direct	Indirect	Invoice	Balance	PDF
View	15GHSU2517	25034-75	University of North Dakota	2/27/2017	$56,163.88	$21,803.41	$77,967.29	$2,736.81	View PDF
View	15GHSU2517	25034-75	University of North Dakota	10/12/2016	$6,354.60	$2,478.30	$8,832.90	$2,736.81	View PDF

Author	Complete Date	Report
Hur, Junguk	2/28/2017	View Progress Report Document
Hur, Junguk	3/1/2017	View Progress Report Document

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