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Causal genes and gene networks for diabetic nephropathy
Summary Data Summary
Applicant Attie, Alan
E-Mail Address adattie@wisc.edu
Project Title Causal genes and gene networks for diabetic nephropathy
CBU ID 13GHSU254
External SubContract ID 25034-35
Diabetic Complication All Complications
Funding Program Group Pilot & Feasibility [PF2013]
Abstract Diabetic nephropathy is the leading cause of end-stage renal disease. We have
developed a model of type 2 diabetes that has turned out to be an excellent
model of human diabetic nephropathy. We have mapped diabetes and
diabetes-related traits in 495 mice from an F2 intercross between our mouse
strain and a strain that is diabetes-resistant. In addition, we have obtained
kidneys from these mice; one kidney was subjected to microarray analysis and the
other to quantitative histological analysis of nephropathy. The histological
analysis is being done collaboratively with Dr. Jeffrey Hodgin (University of
Michigan). The objectives of this pilot study are: 1. Carry out quantitative
trait locus (QTL) mapping of diabetic nephropathy phenotypes in an F2 sample
derived from obese C57BL/6 and BTBR mice. Integrate the disease QTLs with
expression QTLs to develop causal network models underlying the disease. 2.
Derive congenic mouse strains that isolate specific loci and enable positional
cloning of individual diabetic nephropathy genes. The congenic strains will be
new models for individual components of diabetic nephropathy. Our F2 intercross
segregates key features of human diabetic nephropathy. Our work will deliver
individual causal genes for the disease. Perhaps more importantly, we will
develop causal network models that include intermediate traits leading to
diabetic nephropathy. Causal genes and intermediate traits are a potential
source of new therapeutic targets. In summary, this project will deliver QTLs
for diabetic nephropathy, new congenic animal models exhibiting individual
features of the disease, and causal network models providing mechanistic
information, and potentially new therapeutic targets for the disease. Our goal
is to use this preliminary data to obtain an R01 grant a year from now.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 26202
Supply Total Costs 33798
Equipment Total Costs 0
Travel/Other Total Costs 0
Direct Costs 60000
Indirect Costs Proposed 30300
Total Costs Proposed 90300
Total Costs Approved 90300
Start Date 10/1/2013
End Date 9/30/2014
IFO Name Andresen, Robert
IFO E-Mail Address randresen@rsp.wisc.edu
IACUC/IRB No. A00757
IACUC/IRB Institution University of Wisconsin-Madison
Entity ID No.
Report Request Date 10/30/2014
T1D NO
TypeCount
Invoices 10
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  13GHSU25425034-35University of Wisconsin-Madison9/3/2014$20,478.19-$20,478.19$0.50View PDF
  View  13GHSU25425034-35University of Wisconsin-Madison8/4/2014$25,118.96-$25,118.96$0.50View PDF
  View  13GHSU25425034-35University of Wisconsin-Madison7/2/2014$5,426.25-$5,426.25$0.50View PDF
  View  13GHSU25425034-35University of Wisconsin-Madison6/3/2014$2,245.15-$2,245.15$0.50View PDF
  View  13GHSU25425034-35University of Wisconsin-Madison5/2/2014$652.01-$652.01$0.50View PDF
  View  13GHSU25425034-35University of Wisconsin-Madison4/2/2014$3,662.01-$3,662.01$0.50View PDF
  View  13GHSU25425034-35University of Wisconsin-Madison3/4/2014$4,566.37$2,306.02$6,872.39$0.50View PDF
  View  13GHSU25425034-35University of Wisconsin-Madison2/4/2014$2,733.29$1,380.32$4,113.61$0.50View PDF
  View  13GHSU25425034-35University of Wisconsin-Madison11/10/2014$21,078.94-$21,078.94$0.50View PDF
  View  13GHSU25425034-35University of Wisconsin-Madison1/3/2014$433.21$218.78$651.99$0.50View PDF


Reports
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