¿´Æ¬ÊÓƵ

Object moved to here.

¿´Æ¬ÊÓƵ :: Pilot & Feasibility Program Application

¿´Æ¬ÊÓƵ


Autonomic Dysregulation and Enteric Nerve Changes in the Pathophysiology of Diabetic Gastroparesis.
Summary Data Summary
Applicant Abell, Thomas
E-Mail Address thomas.abell@louisville.edu
Project Title Autonomic Dysregulation and Enteric Nerve Changes in the Pathophysiology of
Diabetic Gastroparesis.
CBU ID 13GHSU261
External SubContract ID 25034-32
Diabetic Complication Gastro-Intestinal (GI)
Funding Program Group Pilot & Feasibility [PF2013]
Abstract Previous work on the pathophysiology of diabetic gastroparesis (DM Gp) has
focused on a number of areas, primarily on blood sugar control (BSC), gastric
emptying (GET), and autonomic functioning (ANS), with a more recent emphasis on
electrograms (EGs) and full thickness biopsies (FTB). DM Gp can be viewed as
representing a loss of the normal regulation of the systems measured by these
areas, resulting in the pathophysiologic mechanisms leading to the clinical
manifestations of the disorder of DM Gp. This application explores the
pathophysiology of Diabetic Gastroparesis (DM Gp) and, in particular,
dysregulation in autonomic and enteric mechanisms with the overall goal to
construct a model of the pathophysiology of Diabetic Gastroparesis that
delineates dysregulation of autonomic and enteric pathways.
This protocol has 3 aims: First, to study any associations between gastric
mucosal electrograms (mEG) and gastric mucosal neuronal density (MND) in
clinical DM Gp patients. Second, to investigate mucosal electrograms and gastric
mucosal neuronal density associations and compare them to measures of systemic
autonomic function by heart rate variability (HRV) in consecutive DM Gp
patients. Third, to compare mucosal electrograms, gastric mucosal neuronal
density, and heart rate variability to established measures of serosal
electrograms (sEG), gastric full thickness biopsies (FTB) and traditional
autonomic function testing (ANS) in patients with symptoms of DM Gp. The overall
goal of the study is to construct a model of the pathophysiology of Diabetic
Gastroparesis that delineates dysregulation of autonomic and enteric pathways.
Thus, this protocol allows an investigation of autonomic deregulation and
enteric nerve changes in the pathophysiology of diabetic gastroparesis in three
ways: first, by studying mucosal electrograms and gastric mucosal neuronal
density, secondly, by comparing them to measures of systemic autonomic function
by heart rate variability and thirdly, by comparing the electrograms, gastric
mucosal neuronal density, and heart rate variability to established measures of
serosal electrograms gastric full thickness biopsies and traditional autonomic
function testing.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 40859
Supply Total Costs 13503
Equipment Total Costs 0
Travel/Other Total Costs 25003
Direct Costs 79365
Indirect Costs Proposed 20635
Total Costs Proposed 100000
Total Costs Approved 100000
Start Date 10/1/2013
End Date 9/30/2014
IFO Name King, David
IFO E-Mail Address indcontr@louisville.edu
IACUC/IRB No. 9999
IACUC/IRB Institution University of Louisville
Entity ID No. 1611029626A1
Report Request Date 9/30/2015
T1D NO
TypeCount
Invoices 13
Progress Reports 2
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  13GHSU26125034-32University of Louisville9/11/2015$5,734.26-$5,734.26$10,479.90View PDF
  View  13GHSU26125034-32University of Louisville8/12/2015$1,827.00-$1,827.00$10,479.90View PDF
  View  13GHSU26125034-32University of Louisville8/12/2014$11,029.44-$11,029.44$10,479.90View PDF
  View  13GHSU26125034-32University of Louisville7/24/2014$5,410.98-$5,410.98$10,479.90View PDF
  View  13GHSU26125034-32University of Louisville7/23/2015$630.00-$630.00$10,479.90View PDF
  View  13GHSU26125034-32University of Louisville6/12/2014$5,581.67-$5,581.67$10,479.90View PDF
  View  13GHSU26125034-32University of Louisville5/9/2014$5,410.99-$5,410.99$10,479.90View PDF
  View  13GHSU26125034-32University of Louisville4/11/2014$8,410.08$2,186.62$10,596.70$10,479.90View PDF
  View  13GHSU26125034-32University of Louisville11/30/2014$7,995.78-$7,995.78$10,479.90View PDF
  View  13GHSU26125034-32University of Louisville11/10/2015$6,300.00-$6,300.00$10,479.90View PDF
  View  13GHSU26125034-32University of Louisville10/8/2014$1,479.24-$1,479.24$10,479.90View PDF
  View  13GHSU26125034-32University of Louisville10/12/2015$24,564.78-$24,564.78$10,479.90View PDF
  View  13GHSU26125034-32University of Louisville1/14/2015$2,959.26-$2,959.26$10,479.90View PDF
Click here to cancel and return to funding program application

*Author:
*SubContract:
*Select File:

Click browse and select the file to upload.
(Please upload ONLY TXT, Image Files (not histolgy), PDF, XLS, XLSX, DOC, or DOCX files.)