¿´Æ¬ÊÓƵ

Object moved to here.

¿´Æ¬ÊÓƵ :: Pilot & Feasibility Program Application

¿´Æ¬ÊÓƵ


Molecular Imaging of Stem Cell-Induced Reversal of Vascular Complications and Functions in DM
Summary Data Summary
Applicant Dobrucki, Wawrzyniec
E-Mail Address dobrucki@illinois.edu
Project Title Molecular Imaging of Stem Cell-Induced Reversal of Vascular Complications and
Functions in DM
CBU ID 13GHSU296
External SubContract ID 25732-27
Diabetic Complication Cardiovascular
Funding Program Group Pilot & Feasibility [PF2013]
Abstract Peripheral arterial disease (PAD) is more common and severe among patients with
type-1 diabetes mellitus (DM), results in peripheral ischemia, and is associated
with poor clinical outcome. Traditionally, the treatment of PAD has centered on
smoking cessation, physical exercise, pharmaceutical vasodilation, whereas
current therapies rely on mechanical revascularization through either
percutaneous or surgical approaches. More
recently, with the evolving knowledge of the potential of progenitor and stem
cells as agents of tissue repair, the field of regenerative medicine has moved
toward the use of cell based approaches including use of tissue-derived
mesenchymal stem cells (MSCs). Indeed, initial clinical trials demonstrated
safety and bioactivity of stem cells injected intramuscularly into the ischemic
limbs of patients with PAD. However, there is a need to develop imaging
strategies which will aid to predict hard end points in long-term outcomes.
The principal goal of this project will be to assess the potency of
muscle-derived MSCs (mMSCs) as a novel regenerative therapy to repair and
reverse diabetic vascular complications. During the course of this study, the
mMSCs will be transplanted into ischemic muscle of diabetic and non-diabetic
animals subjected to the surgical ligation of right femoral artery, a
well-characterized animal model of hindlimb ischemia. Following the
transplantation, the pro-angiogenic response of the treatment with mMSCs will be
serially monitored using novel, non-invasive imaging strategy including
evaluation of peripheral angiogenesis (with PET-CT imaging
of avb3 integrin activation), flow recovery (with SPECT-CT imaging of
perfusion), and arteriogenesis (with contrast X-ray CT). These imaging indices
will be directly related to the measures of muscular function and
histopathological evaluations to investigate whether the mMSCs-associated
changes in angiogenesis,
arteriogenesis, and flow will result in the repair and functional recovery of
diabetic muscle.
It is worth to emphasize the translational nature of this project - proposed use
of clinically available imaging modalities and radiotracers currently approved
or being approved in the near future grants potential translation of this
technology to diabetic patients with PAD.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 31367
Supply Total Costs 7978
Equipment Total Costs 0
Travel/Other Total Costs 25610
Direct Costs 64955
Indirect Costs Proposed 29608
Total Costs Proposed 94563
Total Costs Approved 94563
Start Date 10/1/2013
End Date 9/30/2014
IFO Name Moulton, Sandra
IFO E-Mail Address gcopostuiuc@uillinois.edu
IACUC/IRB No. 9999
IACUC/IRB Institution University of Illinois at Urbana-Champaign
Entity ID No. 04-154-4081
Report Request Date 10/30/2014
T1D NO
TypeCount
Invoices 14
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  13GHSU29625732-27University of Illinois at Urbana-Champaign9/10/2014$9,793.47-$9,793.47-View PDF
  View  13GHSU29625732-27University of Illinois at Urbana-Champaign8/6/2015$167.95-$167.95-View PDF
  View  13GHSU29625732-27University of Illinois at Urbana-Champaign8/13/2014$5,175.33-$5,175.33-View PDF
  View  13GHSU29625732-27University of Illinois at Urbana-Champaign7/14/2014$33,210.30-$33,210.30-View PDF
  View  13GHSU29625732-27University of Illinois at Urbana-Champaign6/14/2014$10,999.37-$10,999.37-View PDF
  View  13GHSU29625732-27University of Illinois at Urbana-Champaign5/9/2014$4,617.97-$4,617.97-View PDF
  View  13GHSU29625732-27University of Illinois at Urbana-Champaign4/9/2014$738.58$270.21$1,008.79-View PDF
  View  13GHSU29625732-27University of Illinois at Urbana-Champaign3/13/2014$738.59$270.22$1,008.81-View PDF
  View  13GHSU29625732-27University of Illinois at Urbana-Champaign2/5/2015$3,259.40-$3,259.40-View PDF
  View  13GHSU29625732-27University of Illinois at Urbana-Champaign2/11/2014$220.54$129.24$349.78-View PDF
  View  13GHSU29625732-27University of Illinois at Urbana-Champaign12/9/2014$5,153.66-$5,153.66-View PDF
  View  13GHSU29625732-27University of Illinois at Urbana-Champaign11/11/2014$6,277.53-$6,277.53-View PDF
  View  13GHSU29625732-27University of Illinois at Urbana-Champaign10/9/2014$8,562.15-$8,562.15-View PDF
  View  13GHSU29625732-27University of Illinois at Urbana-Champaign1/13/2015$4,978.49-$4,978.49-View PDF
Click here to cancel and return to funding program application

*Author:
*SubContract:
*Select File:

Click browse and select the file to upload.
(Please upload ONLY TXT, Image Files (not histolgy), PDF, XLS, XLSX, DOC, or DOCX files.)