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Non-Invasive Molecular Imaging in Early Diagnosis of Diabetic Complications
Summary Data Summary
Applicant Hafezi-Moghadam, Ali
E-Mail Address ahm@bwh.harvard.edu
Project Title Non-Invasive Molecular Imaging in Early Diagnosis of Diabetic Complications
CBU ID 13GHSU315
External SubContract ID 25732-30
Diabetic Complication Retinopathy
Funding Program Group Pilot & Feasibility [PF2013]
Abstract Diabetic retinopathy (DR), a microvascular manifestation of diabetes, is a
leading cause of adult vision loss. Early detection and treatment can prevent
vision loss from DR. However, there is currently no way to detect early
molecular or cellular changes in human diabetic patients. Existing methods of
clinical examination only detect the structural damages. Therefore, treatment
usually occurs too late to prevent significant vision deterioration. It would be
of tremendous benefit to the patients, if DR could be diagnosed before the
manifestation of clinical signs of the disease and the occurrence of
irreversible structural damages. Our goal is to develop and establish a
non-invasive molecular imaging technique that in human patients quantitatively
depicts earliest signs of diabetic micro-vasculopathy. Our approach is inspired
by how the organism’s own immune cells detect slightest signs of disease, for
instance during their recruitment to sites of inflammation. We generate
custom-designed imaging probes that bind to specific endothelial markers. Since
the eye provides a unique portal for light-based imaging, the binding
interaction of these agents to retinal microvasculature can be visualized and
will give precise and quantitative knowledge about the status of the retinal
health. This new approach extends the in vivo detection capabilities to the
cellular and molecular level, which amounts to a categorical advancement in
imaging. Our imaging probes provide a distinct type of signal compared to other
molecular imaging approaches, revealing expression and site density of the
molecules to be imaged in vivo. Our aims are to 1) establish our molecular
imaging for early diagnosis of diabetic changes in the retina and use it for
mechanistic studies and identification of new biomarkers of diabetic
retinopathy. Here we investigate adhesion molecules and growth factor receptors
as candidate marker for evaluation of DR, and 2) use molecular imaging in the
retina to gain insights about other diabetic complications that are not as
easily accessible, such as atherosclerosis, kidney or liver changes. Completion
of this research will result in powerful and versatile tools that enable basic
researchers and clinicians to in-depth understanding of the dynamic molecular
and cellular changes that occur in diabetic microvasculopathy, identify and
characterize new molecular markers and test efficacy of new therapeutics.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 60000
Supply Total Costs 25000
Equipment Total Costs 15000
Travel/Other Total Costs 0
Direct Costs 100000
Indirect Costs Proposed 0
Total Costs Proposed 100000
Total Costs Approved 100000
Start Date 10/1/2013
End Date 9/30/2014
IFO Name M, Sheila
IFO E-Mail Address BWHGC@partners.org
IACUC/IRB No. 9999
IACUC/IRB Institution Brigham and Womens Hospital
Entity ID No. 1042312909A1
Report Request Date 10/30/2014
T1D NO
TypeCount
Invoices 9
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  13GHSU31525732-30Brigham and Womens Hospital9/19/2014$9,938.53-$9,938.53-View PDF
  View  13GHSU31525732-30Brigham and Womens Hospital8/11/2014$9,816.15-$9,816.15-View PDF
  View  13GHSU31525732-30Brigham and Womens Hospital7/10/2014$10,826.68-$10,826.68-View PDF
  View  13GHSU31525732-30Brigham and Womens Hospital6/10/2014$9,933.73-$9,933.73-View PDF
  View  13GHSU31525732-30Brigham and Womens Hospital5/9/2014$8,784.92-$8,784.92-View PDF
  View  13GHSU31525732-30Brigham and Womens Hospital4/9/2014$7,128.74-$7,128.74-View PDF
  View  13GHSU31525732-30Brigham and Womens Hospital3/11/2014$7,069.20-$7,069.20-View PDF
  View  13GHSU31525732-30Brigham and Womens Hospital2/11/2014$20,808.00$7,282.80$28,090.80-View PDF
  View  13GHSU31525732-30Brigham and Womens Hospital10/28/2014$8,411.25-$8,411.25-View PDF
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