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Harnessing renal blood flow and oxygenation to manipulate differentiation of nephrons
Summary Data Summary
Applicant Sims-Lucas, Sunder
E-Mail Address simslucass@upmc.edu
Project Title Harnessing renal blood flow and oxygenation to manipulate differentiation of
nephrons
CBU ID 14GHSU344
External SubContract ID 25732-59
Diabetic Complication Nephropathy
Funding Program Group Pilot & Feasibility [PF2014]
Abstract Congenital kidney malformations are one of the leading causes of chronic kidney
disease in children and young adults. The overall functional capacity of the
kidney is dependent upon nephron progenitor differentiation to form the
necessary number of nephrons. The appropriate formation of the developing kidney
is inherently linked to the development of the renal vasculature. Formation of
the renal vasculature involves two vascular processes angiogenesis, the
sprouting of vessels from the major preexisting vessels (largely driven by blood
flow) and vasculogenesis, the de novo formation of blood vessels via resident
precursors (occurs in hypoxic environment). Few studies to date have examined
the role of the renal vasculature and fetal blood flow (including oxygenation)
in nephron formation and kidney development.
Our laboratory has begun using innovative imaging techniques to investigate the
development of vascular networks and fetal blood flow in embryonic mouse
kidneys. Our preliminary data demonstrates that a complex vascular network
(highly integrated with developing nephron structures), renal blood flow, and
glomerular filtration occur early in kidney development. We propose to utilize
three dimensional imaging techniques, combined with immunolabeling of developing
vascular networks and nephron structures to interrogate how the interactions
between these tissues influence the emergence of renal blood flow and
filtration. In collaboration with Dr. Stolz, we will further define how the
specialized vascular beds required for normal kidney function arise using
immunogold electron microscopy. Finally, we will interrogate the role that blood
flow and oxygenation play in mediating nephron progenitor differentiation.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 26444
Supply Total Costs 38491
Equipment Total Costs 0
Travel/Other Total Costs 0
Direct Costs 64935
Indirect Costs Proposed 35065
Total Costs Proposed 100000
Total Costs Approved 100000
Start Date 10/1/2014
End Date 9/30/2015
IFO Name DiPalma, Allen
IFO E-Mail Address offres@offres.pitt.edu
IACUC/IRB No. 13082299
IACUC/IRB Institution University of Pittsburgh-Main Campus
Entity ID No.
Report Request Date 10/30/2015
T1D NO
TypeCount
Invoices 10
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  14GHSU34425732-59University of Pittsburgh-Main Campus9/9/2015$14,753.74-$14,753.74$447.47View PDF
  View  14GHSU34425732-59University of Pittsburgh-Main Campus8/3/2015$10,199.99-$10,199.99$447.47View PDF
  View  14GHSU34425732-59University of Pittsburgh-Main Campus8/10/2015$12,288.80-$12,288.80$447.47View PDF
  View  14GHSU34425732-59University of Pittsburgh-Main Campus7/10/2015$5,268.76-$5,268.76$447.47View PDF
  View  14GHSU34425732-59University of Pittsburgh-Main Campus5/11/2015$8,053.64-$8,053.64$447.47View PDF
  View  14GHSU34425732-59University of Pittsburgh-Main Campus4/9/2015$12,599.29-$12,599.29$447.47View PDF
  View  14GHSU34425732-59University of Pittsburgh-Main Campus3/9/2015$15,829.96-$15,829.96$447.47View PDF
  View  14GHSU34425732-59University of Pittsburgh-Main Campus2/9/2015$6,346.42-$6,346.42$447.47View PDF
  View  14GHSU34425732-59University of Pittsburgh-Main Campus11/23/2015$10,808.70-$10,808.70$447.47View PDF
  View  14GHSU34425732-59University of Pittsburgh-Main Campus1/12/2015$3,403.23-$3,403.23$447.47View PDF
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