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Increased small vessel disease in the brain and cognitive impairment in diabetes

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Applicant	Li, Weiguo
E-Mail Address	liwe@musc.edu
Project Title	Increased small vessel disease in the brain and cognitive impairment in diabetes
CBU ID	17AU3831
External SubContract ID	32307-42
Diabetic Complication	Neuropathy & Neurocognition
Funding Program Group	Pilot & Feasibility [PF2017]
Abstract	Diabetes is an increasing risk factor for vascular cognitive impairment (VCI), which is defined as cognitive deficits associated with small vessel disease (SVD) and/or lacunar infarction due to the occlusion of terminal arterioles by emboli in the brain. Microemboli even in sizes that would not cause complete occlusion are quite common in the cerebral circulation and are more so in patients with diabetes that present with a hypercoagulable state. Lack of understanding of the role and mechanisms by which microemboli can contribute to increased disease burden in diabetes is a critical gap in our knowledge. The objectives of this 看片视频 Pilot & Feasibility Program grant application are to begin addressing this important clinical problem by establishing a novel animal model and gathering proof-of-concept data to implicate the vascular dysfunction and microemboli interaction in the development of cerebral SVD preceding the VCI in diabetes. We propose that the microemboli injected through the internal carotid artery will accelerate the development of cerebral SVD in diabetes ultimately resulting in VCI without increasing microinfarcts in a sex independent manner. We will examine the cerebral neuronal and vascular changes by neuropathology assay in both male and female animals. We will also examine the neurological and cognitive behavioral tests, and brain imaging to assess the cognitive function. The results of this translational study first will provide the proof-of-concept pilot data that microemboli are pathological even in the absence of increased microinfarction in diabetes. Second, we will establish a new clinically relevant model to study the mechanisms of VCI, which will enable us to develop the studies on neurovascular protection strategies especially in the high-risk groups. Third, we will provide novel data regarding the impact of sex on the development of VCI in diabetes.
Application PDF	Application Research Plan
Status	Contract Executed
Key Personnel	Adviye Ergul; Guangkuo Dong;
Salary Total Costs	52911
Supply Total Costs	36498
Equipment Total Costs	0
Travel/Other Total Costs	1500
Direct Costs	90909
Indirect Costs Proposed	9091
Total Costs Proposed	100000
Total Costs Approved	28289.36
Start Date	11/1/2017
End Date	11/30/2019
IFO Name	Wright, Sheree
IFO E-Mail Address	ogc@augusta.edu
IACUC/IRB No.	9999
IACUC/IRB Institution	Augusta University
Entity ID No.
Report Request Date	12/20/2019
T1D	NO

Type	Count
Invoices	3
Progress Reports	2

Data Submission

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Url	CBU ID	External ID	Institution	Date	Direct	Indirect	Invoice	Balance	PDF
View	17AU3831	32307-42	Augusta University	9/18/2019	$6,027.98	$663.07	$6,691.05	$0.36	View PDF
View	17AU3831	32307-42	Augusta University	6/18/2019	$11,440.05	$1,258.41	$12,698.46	$0.36	View PDF
View	17AU3831	32307-42	Augusta University	1/16/2020	$8,249.97	$649.52	$8,899.49	$0.36	View PDF

Author	Complete Date	Report
Li, Weiguo	11/29/2018	View Progress Report Document
Li, Weiguo	12/27/2019	View Progress Report Document

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