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Dolphin-T1D Study: Define Renal Oxygenation Levels and Perfusion in Hyperfiltration in Adolescents with Type 1 Diabetes
Summary Data Summary
Applicant Bjornstad, Petter
E-Mail Address petter.bjornstad@childrenscolorado.org
Project Title Dolphin-T1D Study: Define Renal Oxygenation Levels and Perfusion in
Hyperfiltration in Adolescents with Type 1 Diabetes
CBU ID 18AU3871
External SubContract ID 30835-57
Diabetic Complication Nephropathy
Funding Program Group Pilot & Feasibility [PF2018]
Abstract Diabetic kidney disease (DKD) is the leading cause of renal failure in the
United States, and a major risk factor for cardiovascular disease. Current
treatments, such as control of hyperglycemia and hypertension, are beneficial,
but only partially protective in patients with type 1 diabetes (T1D). Clinical
trials in DKD have yielded disappointing results, partly due to limited
understanding of what initiates DKD, a potentially misguided focus on
albuminuria, and lack of intervention at an early stage of disease when benefit
is most likely. Therefore, identifying new therapeutic targets to impede
progression of DKD remains a public health priority. Early DKD, including
hyperfiltration, is common in youth with T1D. Renal hypoxia, stemming from a
mismatch between renal oxygen utilization and consumption, is increasingly
proposed to be a unifying pathway in the development of DKD. The kidneys have a
high-energy requirement to sustain normal hemodynamic function. However, in T1D,
there are emerging animal data that the kidneys are not able to sufficiently
compensate for hyperfiltration due to the effects of insulin resistance (IR) and
mitochondrial dysfunction on fuel utilization. The pathophysiology underlying
the relationship between early DKD and renal oxygenation (O2) in T1D is unclear.
Accordingly, dedicated translational studies are needed to unravel the complex
metabolic pathophysiology behind the development of DKD. Dr. Bjornstad is a
young NIDDK funded investigator who is committed to patient-oriented research
focused on early DKD. This ¿´Æ¬ÊÓƵ award would provide Dr. Bjornstad with the
support necessary to define renal perfusion and O2 (by MRI) in youth with T1D
with (n=15) and without (n=15) hyperfiltration by blood oxygen level dependent
(BOLD) and arterial spin labeling (ASL) MRI. This innovative application will
capitalize on a Juvenile Diabetes Research Foundation funded study of youth with
T1D undergoing gold standard assessment of intrarenal hemodynamic function by
iohexol and para-aminohippurate clearance. To achieve these goals, Dr. Bjornstad
has assembled a nationally-recognized co-investigator team consisting of Dr.
Kristen Nadeau, Professor of Pediatric Endocrinology at University of Colorado,
Denver (UCD), in addition a Dr. Pottumarthi Prasad (Radiology, U. of Chicago)
and David Z. Cherney (Nephrology, U. of Toronto).
Application PDF Application Research Plan
Status Contract Executed
Key Personnel Petter Bjornstad
Pottumarthi Prasad
Laura Pyle
Kristen Nadeau
David Cherney
Salary Total Costs 15068
Supply Total Costs 7800
Equipment Total Costs 0
Travel/Other Total Costs 24750
Direct Costs 47618
Indirect Costs Proposed 12382
Total Costs Proposed 60000
Total Costs Approved 60000
Start Date 11/1/2018
End Date 10/31/2019
IFO Name Chanthaphonh, Soumontha
IFO E-Mail Address xenia@ucdenver.edu
IACUC/IRB No. 99999
IACUC/IRB Institution University of Colorado at Denver and Health Sciences Center
Entity ID No. 846000555
Report Request Date 12/28/2019
T1D NO
TypeCount
Invoices 8
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  18AU387130835-57University of Colorado at Denver and Health Sciences Center8/9/2019$278.55$72.41$350.96$0.00View PDF
  View  18AU387130835-57University of Colorado at Denver and Health Sciences Center7/22/2019$9,429.26$2,451.60$11,880.86$0.00View PDF
  View  18AU387130835-57University of Colorado at Denver and Health Sciences Center6/18/2019$7,219.27$1,877.00$9,096.27$0.00View PDF
  View  18AU387130835-57University of Colorado at Denver and Health Sciences Center5/14/2019$9,299.17$2,417.79$11,716.96$0.00View PDF
  View  18AU387130835-57University of Colorado at Denver and Health Sciences Center4/17/2019$8,909.25$2,316.41$11,225.66$0.00View PDF
  View  18AU387130835-57University of Colorado at Denver and Health Sciences Center3/19/2019$8,476.00$2,203.76$10,679.76$0.00View PDF
  View  18AU387130835-57University of Colorado at Denver and Health Sciences Center2/25/2019$650.00$169.00$819.00$0.00View PDF
  View  18AU387130835-57University of Colorado at Denver and Health Sciences Center12/27/2019$3,357.55$872.98$4,230.53$0.00View PDF
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