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Evolved metabolic phenotypes for repair in Acomys cahirinus in diabetic nephropathy
Summary Data Summary
Applicant Majesky, Mark
E-Mail Address mwm84@uw.edu
Project Title Evolved metabolic phenotypes for repair in Acomys cahirinus in diabetic
nephropathy
CBU ID 18AU3875
External SubContract ID 34116-2
Diabetic Complication Nephropathy
Funding Program Group Pilot & Feasibility [PF2018]
Abstract Diabetic kidney disease is one of the most severe, progressive, microvascular
complications and is the leading cause of end-stage renal disease in the western
world. Activation or augmentation of endogenous repair-regeneration pathways
represents an optimal treatment strategy to reverse diabetic nephropathy. The
wound healing response that characterizes injury and repair-fibrosis is agnostic
to the specific injury (diabetes): processes such as oxidative stress,
mitochondrial dysfunction, tubular cell death, myofibroblast accumulation and
capillary rarefaction, are common to all scar forming, non-regenerative species.
A striking exception to this sequence is found in the African spiny mouse
(genus: Acomys), a species 20 million years distinct from Mus. Using two models
of aggressive renal injury, our preliminary data show that A. cahirinus repairs
kidney injuries that are routinely fatal in mice (M. musculus) without fibrosis
and restores essentially normal kidney function. In this application, we will
use A.cahirinus as discovery tool to identify novel endogenous
repair-regeneration pathways that can then be applied to established diabetic
nephropathy models. Comparing genome-wide transcriptional responses between
scar-resistant (A. cahirinus) and scar-forming (M. musculus) wound healing in
this ¿´Æ¬ÊÓƵ project is a necessary and important step to developing novel
therapeutic approaches to better manage or prevent diabetic kidney disease.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel Dr. Mark Majesky
Dr. Daryl Okamura
Salary Total Costs 44772
Supply Total Costs 6000
Equipment Total Costs 0
Travel/Other Total Costs 1314
Direct Costs 52086
Indirect Costs Proposed 45992
Total Costs Proposed 98078
Total Costs Approved 98078
Start Date 11/1/2018
End Date 10/31/2019
IFO Name Lausund, Erik
IFO E-Mail Address erik.lausund@seattlechildrens.org
IACUC/IRB No. 99999
IACUC/IRB Institution Seattle Children's Research Institute
Entity ID No. 91-0564748
Report Request Date 1/1/3000
T1D NO
TypeCount
Invoices 7
Progress Reports 0
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  18AU387534116-2Seattle Children's Research Institute9/23/2019$8,300.34$7,138.30$15,438.64$7,435.55View PDF
  View  18AU387534116-2Seattle Children's Research Institute8/28/2019$5,980.49$5,143.23$11,123.72$7,435.55View PDF
  View  18AU387534116-2Seattle Children's Research Institute7/28/2019$4,841.92$4,164.05$9,005.97$7,435.55View PDF
  View  18AU387534116-2Seattle Children's Research Institute6/17/2019$4,212.71$3,256.96$7,469.67$7,435.55View PDF
  View  18AU387534116-2Seattle Children's Research Institute5/15/2019$19,948.74$17,521.88$37,470.62$7,435.55View PDF
  View  18AU387534116-2Seattle Children's Research Institute12/23/2019$251.27$216.09$467.36$7,435.55View PDF
  View  18AU387534116-2Seattle Children's Research Institute10/31/2019$5,197.03$4,469.44$9,666.47$7,435.55View PDF
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