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An Integrated Assessment of Gastric Functions
Summary Data Summary
Applicant Prichard, David
E-Mail Address prichard.david@mayo.edu
Project Title An Integrated Assessment of Gastric Functions
CBU ID 19AU4007
External SubContract ID 32307-52
Diabetic Complication Gastro-Intestinal (GI)
Funding Program Group Pilot & Feasibility [PF2019]
Abstract Upper gastrointestinal (GI) symptoms are experienced by =20% of patients with
diabetes. Dysfunctions of gastric motility, emptying (GE), and accommodation are
postulated to underlie these symptoms. However, the relationship between these
disturbances and daily symptoms is limited. The pathogenesis of delayed (or
rapid) GE in diabetic gastroenteropathy is unclear because the manometric
assessment of gastroduodenal motility is a cumbersome and invasive technique. To
overcome these limitations, we developed a technique to simultaneously measure
GE and gastric motility with scintigraphy. Scintigraphy is the criterion
standard for assessing GE. We also developed a magnetic resonance imaging
(MRI)-based technique to assess gastric motility. Moreover, we have demonstrated
that symptoms during a GE study are correlated with the severity of daily
symptoms. In this study, we propose to integrate the scintigraphic assessment of
GE, gastric antral motility, and the symptoms during a GE study into a single
test. The aims of this research are to: (i) evaluate the relationship between
gastric antral motility and GE assessed with integrated scintigraphy in healthy
people and patients with diabetic gastroenteropathy, (ii) compare gastric antral
motility measured with MRI and scintigraphy, and (iii) evaluate the contribution
of GE, gastric motility, and gastric accommodation (as assessed via MRI), and
symptoms during a GE study, to daily symptoms in patients with diabetic
gastroenteropathy. Ten healthy individuals and 30 patients with diabetes and
upper GI symptoms (10 each with normal, rapid, and delayed GE) will undergo
integrated scintigraphy and a dynamic gastric MRI. We predict that integrated
scintigraphy, which can be performed with existing scanners, will provide a
refined characterization of phenotypes in patients with diabetic
gastroenteropathy, enhance our understanding of the mechanism(s) of delayed (or
rapid) GE, and help identify predictors of the response to medical and/or
endoscopic therapy in future.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 38320
Supply Total Costs 30810
Equipment Total Costs 0
Travel/Other Total Costs 0
Direct Costs 69130
Indirect Costs Proposed 30870
Total Costs Proposed 100000
Total Costs Approved 100000
Start Date 11/1/2019
End Date 10/31/2020
IFO Name Grace, Janice
IFO E-Mail Address researchadmin@mayo.edu
IACUC/IRB No. 99999
IACUC/IRB Institution Mayo Clinic Rochester
Entity ID No.
Report Request Date 11/29/2021
T1D NO
TypeCount
Invoices 7
Progress Reports 2
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  19AU400732307-52Mayo Clinic Rochester6/30/2022$3,660.33$1,623.49$5,283.82$6,844.53View PDF
  View  19AU400732307-52Mayo Clinic Rochester5/31/2022$12,099.97$4,900.91$17,000.88$6,844.53View PDF
  View  19AU400732307-52Mayo Clinic Rochester4/30/2022$16,208.06$4,852.20$21,060.26$6,844.53View PDF
  View  19AU400732307-52Mayo Clinic Rochester3/31/2022$12,666.20$3,592.69$16,258.89$6,844.53View PDF
  View  19AU400732307-52Mayo Clinic Rochester2/28/2022$6,355.13$3,234.37$9,589.50$6,844.53View PDF
  View  19AU400732307-52Mayo Clinic Rochester1/7/2022$1,124.64$663.54$1,788.18$6,844.53View PDF
  View  19AU400732307-52Mayo Clinic Rochester1/31/2022$13,945.87$8,228.07$22,173.94$6,844.53View PDF
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