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Development and validation of ultrasound molecular imaging agents for diabetic kidney disease by measuring bio-molecular interactions聽with a novel, sensitive, homogeneous proximity assay (AlphaScreen鈩)
Summary Data Summary
Applicant Johnson, Kennita
E-Mail Address kennita@email.unc.edu
Project Title Development and validation of ultrasound molecular imaging agents for diabetic
kidney disease by measuring bio-molecular interactions聽with a novel, sensitive,
homogeneous proximity assay (AlphaScreen鈩)
CBU ID 19AU4037
External SubContract ID 32307-54
Diabetic Complication Nephropathy
Funding Program Group Pilot & Feasibility [PF2019]
Abstract Clinical signs of diabetic kidney disease (DKD) manifests years and sometimes
decades after the initial diagnosis of diabetes. During this 鈥渟ilent鈥 time, the
kidney is undergoing molecular changes that will eventually lead to physical
damage. Intercepting the molecular changes with specialized therapies could halt
DKD and prevent the progression to end-stage kidney disease. Not all diabetics
will proceed to DKD; therefore, a sensitive and specific test is necessary to
discern who will eventually develop the disease. Ultrasound molecular imaging is
a potential tool for the early diagnosis of DKD that can report on this
molecular activity at specific sites in the kidney. The goal of this project is
to develop an in vitro assay based on amplified luminescent proximity
homogeneous assay screen to produce sensitive and specific targeted microbubbles
for DKD. The assay will assess and optimize microbubble ligand-receptor
interactions necessary to make the targeted contrast agent. Once the targeted
microbubbles are developed, we will compare the optimized to non-optimized
targeted microbubbles in preclinical models of DKD to assess improvement. The
result will be an assay to quickly generate new targeted microbubbles for
ultrasound molecular imaging. Ultimately, ultrasound molecular imaging will
provide a screening tool for clinicians to detect which diabetic patients will
progress to DKD and offer an opportunity for timely intervention.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel James Tsuruta
Emily Chang
Paul Dayton
Salary Total Costs 28530
Supply Total Costs 7488
Equipment Total Costs 0
Travel/Other Total Costs 3715
Direct Costs 39733
Indirect Costs Proposed 20267
Total Costs Proposed 60000
Total Costs Approved 60000
Start Date 11/1/2019
End Date 10/31/2021
IFO Name Gwaltney, Jennifer
IFO E-Mail Address resadminosr@unc.edu
IACUC/IRB No. 99999
IACUC/IRB Institution University of North Carolina at Chapel Hill
Entity ID No. 56-6001393
Report Request Date 11/29/2021
T1D NO
TypeCount
Invoices 16
Progress Reports 2
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  19AU403732307-54University of North Carolina at Chapel Hill9/9/2020$1,531.69$850.09$2,381.78-View PDF
  View  19AU403732307-54University of North Carolina at Chapel Hill9/14/2021$2,494.92$1,384.67$3,879.59-View PDF
  View  19AU403732307-54University of North Carolina at Chapel Hill8/6/2020$1,685.66$935.57$2,621.23-View PDF
  View  19AU403732307-54University of North Carolina at Chapel Hill8/11/2021$3,106.07$1,723.88$4,829.95-View PDF
  View  19AU403732307-54University of North Carolina at Chapel Hill7/29/2020$9,705.21$5,386.50$15,091.71-View PDF
  View  19AU403732307-54University of North Carolina at Chapel Hill7/19/2021$1,635.30$907.59$2,542.89-View PDF
  View  19AU403732307-54University of North Carolina at Chapel Hill6/15/2021$1,863.93$1,034.51$2,898.44-View PDF
  View  19AU403732307-54University of North Carolina at Chapel Hill5/17/2021$2,755.17$1,529.13$4,284.30-View PDF
  View  19AU403732307-54University of North Carolina at Chapel Hill3/19/2021$1,004.57$557.57$1,562.14-View PDF
  View  19AU403732307-54University of North Carolina at Chapel Hill2/10/2021$2,713.28$1,505.90$4,219.18-View PDF
  View  19AU403732307-54University of North Carolina at Chapel Hill12/8/2020$1,354.02$751.50$2,105.52-View PDF
  View  19AU403732307-54University of North Carolina at Chapel Hill12/20/2021$3,144.75$1,745.35$4,890.10-View PDF
  View  19AU403732307-54University of North Carolina at Chapel Hill11/12/2020$1,561.40$866.61$2,428.01-View PDF
  View  19AU403732307-54University of North Carolina at Chapel Hill11/11/2021$1,549.98$860.31$2,410.29-View PDF
  View  19AU403732307-54University of North Carolina at Chapel Hill10/7/2020$1,651.69$916.71$2,568.40-View PDF
  View  19AU403732307-54University of North Carolina at Chapel Hill10/11/2021$827.30$459.17$1,286.47-View PDF
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