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Sexual Function and Neuropathy in Pre-Diabetes and Type 2 Diabetes
Summary Data Summary
Applicant Sarma, Aruna
E-Mail Address asarma@umich.edu
Project Title Sexual Function and Neuropathy in Pre-Diabetes and Type 2 Diabetes
CBU ID 20AU4106
External SubContract ID 30835-70
Diabetic Complication Neuropathy & Neurocognition
Funding Program Group Pilot & Feasibility [PF2020]
Abstract A common health problem among both men and women, sexual dysfunction increases
with advancing age and markedly reduces quality of life (QOL). Our team’s
findings from people with type 1 diabetes (T1DM) in the Epidemiology of
Diabetes, Interventions and Complications (EDIC) study–the observational
extension of the Diabetes Control and Complications Trial (DCCT)–showed that 45%
of men reported erectile dysfunction (ED) and 42% of women reported female
sexual dysfunction (FSD). Poor glycemic control and cardiac autonomic neuropathy
significantly increased risk of ED and FSD in this cohort. Although our findings
in EDIC have begun to shed light on the role of prevalent T1DM on sexual
dysfunction, data defining the burden, and risk reduction strategies among
people who are at risk for type 2 diabetes (T2DM) are limited. The Diabetes
Prevention Program (DPP), a randomized controlled trial of overweight and obese
men and women at high risk for T2DM, and its observational follow up, the
Diabetes Prevention Program Observational Study (DPPOS) now in its 18th year,
demonstrated that intense lifestyle intervention and metformin both delayed the
onset and progression of T2DM and its complications. At year 15, DPPOS
participants completed the International Index of Erectile Function (IIEF) and
Female Sexual Function Index (FSFI) yielding validated measures of sexual
dysfunction for both genders. We hypothesize that sexual dysfunction in men and
women with prediabetes and T2DM is highly prevalent and less favorable
trajectories of glycemia and neuropathy predict those at highest risk.
Accordingly, we propose to utilize existing data from DPPOS to test these
hypotheses. By fully leveraging data in an existing, NIH-funded study, we avoid
costs associated with primary data collection and facilitate generation of new
knowledge that (1) builds on a growing body of research on the urological
complications of DM and (2) has been defined as a high priority to the NIH and
other stakeholders.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel Rodica Pop-Busui
Marinella Temprosa
Salary Total Costs 33456
Supply Total Costs 0
Equipment Total Costs 0
Travel/Other Total Costs 25909
Direct Costs 59365
Indirect Costs Proposed 40635
Total Costs Proposed 100000
Total Costs Approved 100000
Start Date 11/1/2020
End Date 10/31/2021
IFO Name Dill, Debra
IFO E-Mail Address dldill@umich.edu
IACUC/IRB No. 99999
IACUC/IRB Institution Regents of the University of Michigan
Entity ID No.
Report Request Date 10/31/2021
T1D NO
TypeCount
Invoices 11
Progress Reports 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  20AU410630835-70Regents of the University of Michigan9/24/2021$3,349.71$1,875.84$5,225.55$691.12View PDF
  View  20AU410630835-70Regents of the University of Michigan8/5/2021$3,416.54$1,913.26$5,329.80$691.12View PDF
  View  20AU410630835-70Regents of the University of Michigan7/7/2021$3,425.67$1,918.38$5,344.05$691.12View PDF
  View  20AU410630835-70Regents of the University of Michigan6/4/2021$3,441.55$1,927.27$5,368.82$691.12View PDF
  View  20AU410630835-70Regents of the University of Michigan5/6/2021$3,441.54$1,927.26$5,368.80$691.12View PDF
  View  20AU410630835-70Regents of the University of Michigan4/6/2021$3,441.54$1,927.26$5,368.80$691.12View PDF
  View  20AU410630835-70Regents of the University of Michigan3/4/2021$3,451.16$1,932.65$5,383.81$691.12View PDF
  View  20AU410630835-70Regents of the University of Michigan2/4/2021$5,163.57$2,891.60$8,055.17$691.12View PDF
  View  20AU410630835-70Regents of the University of Michigan11/4/2021$3,350.99$1,876.55$5,227.54$691.12View PDF
  View  20AU410630835-70Regents of the University of Michigan10/6/2021$28,064.46$15,716.10$43,780.56$691.12View PDF
  View  20AU410630835-70Regents of the University of Michigan1/7/2021$3,112.81$1,743.17$4,855.98$691.12View PDF


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