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Quantifying Structural Changes in the Diabetic Foot using Three-dimensional Ultrasound
Summary Data Summary
Applicant Ledoux, William
E-Mail Address wrledoux@uw.edu
Project Title Quantifying Structural Changes in the Diabetic Foot using Three-dimensional
Ultrasound
CBU ID 21AU4226
External SubContract ID 32307-94
Diabetic Complication Wound Healing
Funding Program Group Pilot & Feasibility [PF2021]
Abstract Diabetes mellitus can lead to severe complications of the lower extremity,
including ulceration and subsequent amputation. Nearly two thirds of all
non-traumatic amputations in the U.S. occur in persons with diabetes. Developing
improved treatment options requires a better fundamental understanding of
diabetic disease pathomechanics. Despite growing agreement that aberrant
pressures and shear stresses are linked to ulceration, the specific causative
mechanism of ulceration remains poorly understood. The changes in the
biomechanics of the foot due to diabetes have been investigated from a material
perspective (e.g., isolated plantar fat) and a full body motion analysis
perspective (e.g., joint range of motion). From a structural perspective—in
which tissues of different material properties and different geometries interact
to create a bulk response—most studies have been two dimensional and limited in
the number of locations considered. Given the complex structure and functional
motion of the foot, it should be investigated in three dimensions across the
entire plantar surface. However, many techniques that afford volumetric inquiry
have other concerns: dissection is disruptive, finite element models rely on
assumptions and simplifications, computed tomography has poor soft tissue
resolution, and MRI is computationally and fiscally expensive. Ultrasound has
good soft tissue resolution, but most commercial systems create planar images or
are limited to small, angularly swept volumes. Ultrasound can also be difficult
to read for the naïve user. In order to overcome these barriers, we propose
these specific aims: 1) Develop a mechanical system and the necessary software
to generate a three-dimensional scan of the entire plantar soft tissue, using
B-mode ultrasound for structural information and shear wave elastography for
tissue properties. 2) Collect plantar soft tissue scans for 7 diabetic
non-neuropathic subjects and 7 non-diabetic subjects. 3) Analyze these scans
using segmentation and strain information calculated with digital volume
correlation as well as an interpretable classification neural network. The
successful completion of this pilot study will demonstrate the utility of the
proposed methods and generate the necessary data for a power analysis to support
an R01 grant application.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel William Ledoux
Kristina Utzschneider
Eric Rombokas
Michael Bailey
Salary Total Costs 17495
Supply Total Costs 2750
Equipment Total Costs 0
Travel/Other Total Costs 23808
Direct Costs 44053
Indirect Costs Proposed 15947
Total Costs Proposed 60000
Total Costs Approved 54000
Start Date 7/1/2021
End Date 6/30/2022
IFO Name Alexander, Elena
IFO E-Mail Address elena@sibcr.org
IACUC/IRB No. 99999
IACUC/IRB Institution VA Puget Sound Health Care System
Entity ID No. 020232971
Report Request Date 6/30/2023
T1D NO
TypeCount
Invoices 15
Progress Reports 2
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  21AU422632307-94VA Puget Sound Health Care System9/30/2022$27,956.92$9,956.60$37,913.52$5,021.53View PDF
  View  21AU422632307-94VA Puget Sound Health Care System8/31/2022$705.07$255.24$960.31$5,021.53View PDF
  View  21AU422632307-94VA Puget Sound Health Care System7/31/2023$853.53$308.98$1,162.51$5,021.53View PDF
  View  21AU422632307-94VA Puget Sound Health Care System7/28/2022$274.91$99.52$374.43$5,021.53View PDF
  View  21AU422632307-94VA Puget Sound Health Care System6/30/2022$1,903.08$688.91$2,591.99$5,021.53View PDF
  View  21AU422632307-94VA Puget Sound Health Care System6/29/2023$963.13$348.65$1,311.78$5,021.53View PDF
  View  21AU422632307-94VA Puget Sound Health Care System5/31/2023$410.58$148.63$559.21$5,021.53View PDF
  View  21AU422632307-94VA Puget Sound Health Care System5/31/2022$690.57$249.99$940.56$5,021.53View PDF
  View  21AU422632307-94VA Puget Sound Health Care System4/28/2023$477.00$172.67$649.67$5,021.53View PDF
  View  21AU422632307-94VA Puget Sound Health Care System3/30/2023$780.94$282.70$1,063.64$5,021.53View PDF
  View  21AU422632307-94VA Puget Sound Health Care System2/28/2023$100.51$36.38$136.89$5,021.53View PDF
  View  21AU422632307-94VA Puget Sound Health Care System12/30/2022$167.42$60.61$228.03$5,021.53View PDF
  View  21AU422632307-94VA Puget Sound Health Care System11/30/2022$160.65$58.15$218.80$5,021.53View PDF
  View  21AU422632307-94VA Puget Sound Health Care System10/31/2022$576.99$208.87$785.86$5,021.53View PDF
  View  21AU422632307-94VA Puget Sound Health Care System1/31/2023$59.67$21.60$81.27$5,021.53View PDF
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