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The role of TLR-mediated inflammation in diabetic cardiomyopathy
Summary Data Summary
Applicant Schaffer, Jean
E-Mail Address jschaff@wustl.edu
Project Title The role of TLR-mediated inflammation in diabetic cardiomyopathy
CBU ID 09MCG62
External SubContract ID 23789-10
Diabetic Complication Cardiovascular
Funding Program Group Pilot & Feasibility [PF2009]
Abstract Cardiovascular disease is the leading cause of death in diabetics who suffer
from aggressive atherosclerosis and cardiomyopathy. Inflammation is now
recognized as a central feature of obesity, insulin resistance, and diabetes.
Nonetheless, the role of inflammatory pathways in the pathogenesis of diabetic
cardiac dysfunction has been largely unexplored. Evidence is emerging that
Toll-like receptor (TLR) 4 and 2, originally identified as host receptors for
bacterial lipids and lipoproteins such as lipopolysaccharide (LPS), contribute
to systemic insulin resistance in lipid overload states through a mechanism that
may involve activation by saturated fatty acids. Our preliminary studies
demonstrate alterations in myocardial lipid metabolism can activate inflammatory
signaling in vivo. We will use mouse models of lipotoxic cardiomyopathy and
diabetic cardiomyopathy combined with TLR4 and TLR2 loss of function to test the
hypothesis that TLR-mediated inflammatory signaling contributes to the
pathogenesis of diabetic cardiac dysfunction.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 20358
Supply Total Costs 5600
Equipment Total Costs 0
Travel/Other Total Costs 13516
Direct Costs 39474
Indirect Costs Proposed 20526
Total Costs Proposed 60000
Total Costs Approved 63000
Start Date 9/1/2009
End Date 8/31/2011
IFO Name Michnowicz, John
IFO E-Mail Address G&C@msnotes.edu
IACUC/IRB No. 20070207
IACUC/IRB Institution Washington University in St Louis
Entity ID No. 1430653611A1
Report Request Date 9/30/2010
T1D NO
TypeCount
Invoices 0
Progress Reports 1
Data Submission


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