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Novel MRI Imaging Biomarkers for Diabetic Complications
Summary Data Summary
Applicant Dell, Katherine
E-Mail Address katherine.dell@case.edu
Project Title Novel MRI Imaging Biomarkers for Diabetic Complications
CBU ID 09MCG76
External SubContract ID 23789-6
Diabetic Complication Nephropathy
Funding Program Group Pilot & Feasibility [PF2009]
Abstract Type II diabetes mellitus (DM) affects millions of people worldwide and causes a
myriad of complications that affect multiple organs in the body, including
kidneys, heart, vasculature, gastrointestinal system, skin and eyes. These
complications contribute to significant morbidity and mortality in diabetic
patients; however, not all patients with DM these complications. Thus, it is of
utmost importance to detect complications at the early stages of disease before
irreversible damage has occurred, so that specific interventions can be targeted
to high risk populations. Unfortunately, many of the clinical indicators of
"end-organ" involvement are not evident until substantial damage has occurred.
This challenge highlights the importance of developing non-invasive, clinically
applicable biomarkers of early disease. Newer, quantitative magnetic resonance
imaging (MRI) techniques, such as Iterative Decomposition of water and fat with
Echo Asymmetry and Least-squares estimation (IDEAL) and Magnetization Transfer
MRI (MT-MRI), have the potential to detect early disease but have not been
rigorously studied in human or animal models of DM. The proposed studies will
apply these quantitative techniques to the study of two diabetic complications:
diabetic nephropathy (DN) and non-alcoholic fatty liver disease (NAFLD). The
overall hypothesis is that MRI imaging techniques can be used as quantitative
biomarkers to monitor progression of diabetic and kidney and liver disease in
the early stages of disease. The proposed studies will use the db/db mouse, a
well-characterized DM model that develops features of DN and fatty liver
disease. The specific aim of the proposal to develop MRI imaging techniques to
assess the development of nephropathy and fatty liver disease in the db/db
mouse. Db/db animals will be imaged serially at different ages using the
quantitative MRI imaging techniques, MT-MRI (to assess kidney collagen and
hypertrophy) and IDEAL (to assess liver fat deposition). MRI results will be
correlated with histologic/biochemical and clinical assessments, in order to
determine the applicability of these techniques to detecting early kidney and
liver disease and monitoring disease progression.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 22852
Supply Total Costs 15365
Equipment Total Costs 0
Travel/Other Total Costs 0
Direct Costs 38217
Indirect Costs Proposed 21783
Total Costs Proposed 60000
Total Costs Approved 63000
Start Date 9/1/2009
End Date 8/31/2011
IFO Name Sideras, John
IFO E-Mail Address john.sideras@case.edu
IACUC/IRB No. 2006-0124
IACUC/IRB Institution Case Western Reserve
Entity ID No. A3145-01
Report Request Date 9/30/2010
T1D NO
TypeCount
Invoices 0
Progress Reports 1
Data Submission


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