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Noninvasive evaluation of diabetic nephropathy using magnetization transfer MRI
Summary Data Summary
Applicant Takahashi, Takamune
E-Mail Address takamune.takahashi@vanderbilt.edu
Project Title Noninvasive evaluation of diabetic nephropathy using magnetization transfer MRI
CBU ID 15GHSU2490
External SubContract ID 25034-71
Diabetic Complication Nephropathy
Funding Program Group Pilot & Feasibility [PF2015]
Abstract Diabetic nephropathy (DN) is a major diabetic complication that determines the
morbidity and mortality of the diabetic patients. However, currently available
clinical tests or risk factors do not reliably assess its severity or
progression in individual patients, making it difficult to do the targeted and
intensified treatment to high-risk patient populations. One of the major
limitations of current tests is their inability to reliably assess the extent of
renal fibrosis in the affected kidney, even though renal fibrosis is the most
important pathological change to evaluate or predict the long-term outcome of
the patient. Although renal biopsy can diagnose fibrosis, it is invasive and
prone to sampling errors, and does not reliably measure renal fibrosis in the
affected kidney. Thus, a non-invasive test that better evaluate renal fibrosis
in diabetic kidney should greatly improve the assessment of this disease,
enabling better treatment protocol and prognosis.In recent decade, a variety of
magnetic resonance imaging (MRI) methods have been developed andapplied to human
disease including cancer and brain disorders. These techniques have enabled us
toassess the pathological changes in disease organ at molecular and cellular
levels. Magnetization transfer(MT) imaging is a MRI technique that evaluates
large and immobile macromolecules distributed within thetissue and could provide
a means to evaluate the pathological events that are accompanied by the changes
of macromolecular components, such as fibrosis and apoptosis. However, this
method is poorly applied to kidney disease including DN. Therefore, here we will
evaluate the utility of MT imaging in measuring renal fibrosis in diabetic
kidney using a mouse model of progressive DN (db/db eNOS -/- mice). The aims of
thisstudy are: 1) To optimize and establish the MT protocol for mouse kidney
imaging; 2) To examine the correlation between MT data and histological or
biochemical measures of renal fibrosis. Thus, thisapplication explores a new MRI
test to assess renal fibrosis in DN. Given the fact that this MRI technique can
be translated to clinics, the present work should efficiently improve the
outcome of the patients with DN.
Application PDF Application Research Plan
Status Contract Executed
Key Personnel
Salary Total Costs 27603
Supply Total Costs 3591
Equipment Total Costs 0
Travel/Other Total Costs 32500
Direct Costs 63694
Indirect Costs Proposed 36306
Total Costs Proposed 100000
Total Costs Approved 90000
Start Date 10/1/2015
End Date 3/31/2017
IFO Name Brown, D.Clinton
IFO E-Mail Address SponsoredPrograms@vanderbilt.edu
IACUC/IRB No. 99999
IACUC/IRB Institution Vanderbilt University
Entity ID No. 62-0476822
Report Request Date 3/31/2017
T1D NO
TypeCount
Invoices 11
Progress Reports 1
Experiments 1
Data Submission


Invoices
UrlCBU IDExternal IDInstitutionDateDirectIndirectInvoiceBalancePDF
  View  15GHSU249025034-71Vanderbilt University8/5/2016$4,249.20$2,422.04$6,671.24$508.82View PDF
  View  15GHSU249025034-71Vanderbilt University7/19/2016$3,879.87$2,211.53$6,091.40$508.82View PDF
  View  15GHSU249025034-71Vanderbilt University7/11/2017---$508.82View PDF
  View  15GHSU249025034-71Vanderbilt University6/8/2016$4,206.68$2,397.81$6,604.49$508.82View PDF
  View  15GHSU249025034-71Vanderbilt University5/18/2016$3,568.60$2,034.10$5,602.70$508.82View PDF
  View  15GHSU249025034-71Vanderbilt University5/17/2017$26,809.98$15,549.79$42,359.77$508.82View PDF
  View  15GHSU249025034-71Vanderbilt University4/8/2016$3,375.42$1,923.99$5,299.41$508.82View PDF
  View  15GHSU249025034-71Vanderbilt University2/5/2016$4,462.68-$4,462.68$508.82View PDF
  View  15GHSU249025034-71Vanderbilt University11/11/2016$2,422.91$1,381.06$3,803.97$508.82View PDF
  View  15GHSU249025034-71Vanderbilt University1/11/2016$4,272.68-$4,272.68$508.82View PDF
  View  15GHSU249025034-71Vanderbilt University $2,773.69$1,581.00$4,354.69$508.82View PDF


Experiments
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